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Mouse Anti-CTRC Recombinant Antibody (4E1) (CBMAB-C1810-LY)

This product is antibody recognizes CTRC. The antibody 4E1 immunoassay techniques such as: ELISA, WB, IHC.
See all CTRC antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
4E1
Antibody Isotype
IgG3
Application
ELISA, WB, IHC

Basic Information

Immunogen
Purified human pancreatic chymotrypsin
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG3
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Chymotrypsin C
Introduction
CTRC (Chymotrypsin C) is a Protein Coding gene. Diseases associated with CTRC include Pancreatitis, Hereditary and Tropical Calcific Pancreatitis. Among its related pathways are Metabolism and Metabolism of water-soluble vitamins and cofactors. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity and peptidase activity.
An important paralog of this gene is CELA2A.
Entrez Gene ID
Human11330
Mouse76701
Rat362653
UniProt ID
HumanQ99895
MouseQ3SYP2
RatP55091
Alternative Names
Chymotrypsin C; Caldecrin; Elastase 4; CLCR; Serum Calcium Decreasing Factor; Chymotrypsin C (Caldecrin);
Function
Regulates activation and degradation of trypsinogens and procarboxypeptidases by targeting specific cleavage sites within their zymogen precursors. Has chymotrypsin-type protease activity and hypocalcemic activity.
Biological Process
Cellular calcium ion homeostasis Source: MGI
Cobalamin metabolic process Source: Reactome
Proteolysis Source: MGI
Cellular Location
Extracellular region
Involvement in disease
Pancreatitis, hereditary (PCTT):
Disease susceptibility is associated with variants affecting the gene represented in this entry. Loss-of-function CTRC variants predispose to pancreatitis by diminishing its protective trypsin-degrading activity (PubMed:18059268). They cause loss of function by one or more of three mechanisms: reduced secretion, catalytic defect and increased degradation by trypsin (PubMed:22942235).
A disease characterized by pancreas inflammation, permanent destruction of the pancreatic parenchyma, maldigestion, and severe abdominal pain attacks.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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