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Rat Anti-CTSA Recombinant Antibody (CBXC-1486) (CBMAB-C3608-CQ)

This product is a rat antibody that recognizes CTSA. The antibody CBXC-1486 can be used for immunoassay techniques such as: IHC, WB.
See all CTSA antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBXC-1486
Antibody Isotype
IgG2
Application
IHC, WB

Basic Information

Immunogen
Recombinant protein corresponding to mouse Cathepsin-A
Specificity
Mouse
Antibody Isotype
IgG2
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
Lyophilized powder from PBS. Reconstitute with 200 μL PBS
Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cathepsin A
Introduction
CTSA (Cathepsin A) is a Protein Coding gene. Diseases associated with CTSA include Galactosialidosis and Glycoproteinosis. Among its related pathways are Metabolism of proteins and Transport to the Golgi and subsequent modification. Gene Ontology (GO) annotations related to this gene include enzyme activator activity and serine-type carboxypeptidase activity.
Entrez Gene ID
19025
UniProt ID
Q9D2D1
Alternative Names
Cathepsin A; Carboxypeptidase C; Carboxypeptidase Y-Like Kininase; Protective Protein Cathepsin A; Lysosomal Protective Protein; Lysosomal Carboxypeptidase A; Carboxypeptidase-L; Urinary Kininase; EC 3.4.16.5; Deamidase; PPGB;
Function
Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins.
Biological Process
Glycosphingolipid metabolic process Source: Reactome
Intracellular protein transport Source: ProtInc
Negative regulation of chaperone-mediated autophagy Source: ParkinsonsUK-UCL
Neutrophil degranulation Source: Reactome
Proteolysis Source: ParkinsonsUK-UCL
Regulation of chaperone-mediated autophagy Source: ParkinsonsUK-UCL
Regulation of protein stability Source: ParkinsonsUK-UCL
Cellular Location
Lysosome
Involvement in disease
Galactosialidosis (GSL):
A lysosomal storage disease associated with a combined deficiency of beta-galactosidase and neuraminidase, secondary to a defect in cathepsin A. All patients have clinical manifestations typical of a lysosomal disorder, such as coarse facies, cherry red spots, vertebral changes, foam cells in the bone marrow, and vacuolated lymphocytes. Three phenotypic subtypes are recognized. The early infantile form is associated with fetal hydrops, edema, ascites, visceromegaly, skeletal dysplasia, and early death. The late infantile type is characterized by hepatosplenomegaly, growth retardation, cardiac involvement, and a normal or mildly affected mental state. The juvenile/adult form is characterized by myoclonus, ataxia, angiokeratoma, mental retardation, neurologic deterioration, absence of visceromegaly, and long survival.

Wang, H., Xu, F., Yang, F., Lv, L., & Jiang, Y. (2021). Prognostic significance and oncogene function of cathepsin A in hepatocellular carcinoma. Scientific Reports, 11(1), 1-15.

Park, S., Kwon, W., Park, J. K., Baek, S. M., Lee, S. W., Cho, G. J., ... & Choi, S. K. (2020). Suppression of cathepsin a inhibits growth, migration, and invasion by inhibiting the p38 MAPK signaling pathway in prostate cancer. Archives of Biochemistry and Biophysics, 688, 108407.

Hu, B., Zhu, X., & Lu, J. (2020). Cathepsin A knockdown decreases the proliferation and invasion of A549 lung adenocarcinoma cells. Molecular Medicine Reports, 21(6), 2553-2559.

Kim, J. W., Mahiddine, F. Y., & Kim, G. A. (2020). Leptin modulates the metastasis of canine inflammatory mammary adenocarcinoma cells through downregulation of lysosomal protective protein cathepsin a (Ctsa). International journal of molecular sciences, 21(23), 8963.

Toss, M. S., Miligy, I. M., Haj‐Ahmad, R., Gorringe, K. L., AlKawaz, A., Mittal, K., ... & Rakha, E. A. (2019). The prognostic significance of lysosomal protective protein (cathepsin A) in breast ductal carcinoma in situ. Histopathology, 74(7), 1025-1035.

Nakajima, H., Ueno, M., Adachi, K., Nanba, E., Narita, A., Tsukimoto, J., ... & Kawakami, A. (2019). A new heterozygous compound mutation in the CTSA gene in galactosialidosis. Human genome variation, 6(1), 1-5.

Ni, S., Weng, W., Xu, M., Wang, Q., Tan, C., Sun, H., ... & Sheng, W. (2018). miR-106b-5p inhibits the invasion and metastasis of colorectal cancer by targeting CTSA. OncoTargets and therapy, 11, 3835.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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