CTSA
CTSA (Cathepsin A) is a Protein Coding gene. Diseases associated with CTSA include Galactosialidosis and Glycoproteinosis. Among its related pathways are Metabolism of proteins and Transport to the Golgi and subsequent modification. Gene Ontology (GO) annotations related to this gene include enzyme activator activity and serine-type carboxypeptidase activity.
Full Name
Cathepsin A
Function
Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins.
Biological Process
Glycosphingolipid metabolic process Source: Reactome
Intracellular protein transport Source: ProtInc
Negative regulation of chaperone-mediated autophagy Source: ParkinsonsUK-UCL
Neutrophil degranulation Source: Reactome
Proteolysis Source: ParkinsonsUK-UCL
Regulation of chaperone-mediated autophagy Source: ParkinsonsUK-UCL
Regulation of protein stability Source: ParkinsonsUK-UCL
Intracellular protein transport Source: ProtInc
Negative regulation of chaperone-mediated autophagy Source: ParkinsonsUK-UCL
Neutrophil degranulation Source: Reactome
Proteolysis Source: ParkinsonsUK-UCL
Regulation of chaperone-mediated autophagy Source: ParkinsonsUK-UCL
Regulation of protein stability Source: ParkinsonsUK-UCL
Cellular Location
Lysosome
Involvement in disease
Galactosialidosis (GSL):
A lysosomal storage disease associated with a combined deficiency of beta-galactosidase and neuraminidase, secondary to a defect in cathepsin A. All patients have clinical manifestations typical of a lysosomal disorder, such as coarse facies, cherry red spots, vertebral changes, foam cells in the bone marrow, and vacuolated lymphocytes. Three phenotypic subtypes are recognized. The early infantile form is associated with fetal hydrops, edema, ascites, visceromegaly, skeletal dysplasia, and early death. The late infantile type is characterized by hepatosplenomegaly, growth retardation, cardiac involvement, and a normal or mildly affected mental state. The juvenile/adult form is characterized by myoclonus, ataxia, angiokeratoma, mental retardation, neurologic deterioration, absence of visceromegaly, and long survival.
A lysosomal storage disease associated with a combined deficiency of beta-galactosidase and neuraminidase, secondary to a defect in cathepsin A. All patients have clinical manifestations typical of a lysosomal disorder, such as coarse facies, cherry red spots, vertebral changes, foam cells in the bone marrow, and vacuolated lymphocytes. Three phenotypic subtypes are recognized. The early infantile form is associated with fetal hydrops, edema, ascites, visceromegaly, skeletal dysplasia, and early death. The late infantile type is characterized by hepatosplenomegaly, growth retardation, cardiac involvement, and a normal or mildly affected mental state. The juvenile/adult form is characterized by myoclonus, ataxia, angiokeratoma, mental retardation, neurologic deterioration, absence of visceromegaly, and long survival.
View more
Anti-CTSA antibodies
+ Filters
Loading...
CompareTarget: CTSA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-0989
Application*: E
Target: CTSA
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: 4A12
Application*: IH, WB
Target: CTSA
Sensitivity: 0.005 ng/mL
Detection Range: 0.01-2 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: CTSA
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-474
Tag: His Tag
Target: CTSA
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-480
Tag: His Tag
Target: CTSA
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBCNC-467
Application*: WB, IP
Target: CTSA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C2307
Application*: E
Target: CTSA
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBFYC-2428
Application*: WB, IP
Target: CTSA
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYC-2427
Application*: WB, IP
Target: CTSA
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBFYC-2424
Application*: IP, IH
Target: CTSA
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBFYC-2423
Application*: WB
Target: CTSA
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 108
Application*: E, IF
Target: CTSA
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: 104
Application*: E
More Infomation
Hot products 
-
Mouse Anti-CA9 Recombinant Antibody (CBXC-2079) (CBMAB-C0131-CQ)
-
Mouse Anti-ASB9 Recombinant Antibody (1D8) (CBMAB-A0529-LY)
-
Mouse Anti-ARID3A Antibody (A4) (CBMAB-0128-YC)
-
Mouse Anti-AAV8 Recombinant Antibody (V2-634028) (CBMAB-AP022LY)
-
Mouse Anti-CALR Recombinant Antibody (CBFYC-0763) (CBMAB-C0818-FY)
-
Rat Anti-FABP3 Recombinant Antibody (CBXF-2299) (CBMAB-F1612-CQ)
-
Mouse Anti-CASP7 Recombinant Antibody (10-01-62) (CBMAB-C2005-LY)
-
Mouse Anti-AZGP1 Recombinant Antibody (CBWJZ-007) (CBMAB-Z0012-WJ)
-
Mouse Anti-CD33 Recombinant Antibody (P67.6) (CBMAB-C10189-LY)
-
Mouse Anti-FOXA3 Recombinant Antibody (2A9) (CBMAB-0377-YC)
-
Rabbit Anti-BRCA2 Recombinant Antibody (D9S6V) (CBMAB-CP0017-LY)
-
Mouse Anti-CD24 Recombinant Antibody (ALB9) (CBMAB-0176CQ)
-
Mouse Anti-APP Recombinant Antibody (5C2A1) (CBMAB-A3314-YC)
-
Rat Anti-(1-5)-α-L-Arabinan Recombinant Antibody (V2-501861) (CBMAB-XB0003-YC)
-
Mouse Anti-ACE2 Recombinant Antibody (V2-179293) (CBMAB-A0566-YC)
-
Mouse Anti-CD33 Recombinant Antibody (6C5/2) (CBMAB-C8126-LY)
-
Mouse Anti-FPR2 Recombinant Antibody (1D6) (CBMAB-F2628-CQ)
-
Rabbit Anti-DLK1 Recombinant Antibody (9D8) (CBMAB-D1061-YC)
-
Mouse Anti-BCL6 Recombinant Antibody (CBYY-0435) (CBMAB-0437-YY)
-
Mouse Anti-ADGRL2 Recombinant Antibody (V2-58519) (CBMAB-L0166-YJ)
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
Online Inquiry