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Mouse Anti-CTSG Recombinant Antibody (CBFYC-2449) (CBMAB-C2522-FY)

This product is mouse antibody that recognizes CTSG. The antibody CBFYC-2449 can be used for immunoassay techniques such as: WB, IHC-P.
See all CTSG antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYC-2449
Antibody Isotype
IgG1
Application
WB, IHC-P

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cathepsin G
Introduction
CTSG (Cathepsin G) is a Protein Coding gene. Diseases associated with CTSG include Vasculitis and Cutaneous Mastocytosis. Among its related pathways are Peptide hormone metabolism and Innate Immune System. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity and peptidase activity. An important paralog of this gene is GZMB.
Entrez Gene ID
1511
UniProt ID
P08311
Alternative Names
Cathepsin G; CG; EC 3.4.21.20; EC 3.4.21; CATG
Function
Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial activity is inhibited by LPS from P.aeruginosa, Z-Gly-Leu-Phe-CH2Cl and phenylmethylsulfonyl fluoride.
Biological Process
Angiotensin maturation Source: Reactome
Antibacterial humoral response Source: UniProtKB
Antimicrobial humoral response Source: Reactome
Cellular protein metabolic process Source: Reactome
Cellular response to lipopolysaccharide Source: UniProtKB
Cytokine-mediated signaling pathway Source: Reactome
Defense response to fungus Source: Ensembl
Defense response to Gram-negative bacterium Source: UniProtKB
Extracellular matrix disassembly Source: Reactome
Immune response Source: ProtInc
Negative regulation by symbiont of host apoptotic process Source: Reactome
Neutrophil degranulation Source: Reactome
Neutrophil-mediated killing of gram-positive bacterium Source: Ensembl
Positive regulation of immune response Source: Ensembl
Protein phosphorylation Source: CACAO
Proteolysis Source: UniProtKB
Purinergic nucleotide receptor signaling pathway Source: Reactome
Cellular Location
Cell surface

Huang, G. Z., Wu, Q. Q., Zheng, Z. N., Shao, T. R., Li, F., Lu, X. Y., ... & Lv, X. Z. (2021). Bioinformatics analyses indicate that Cathepsin G (CTSG) is a potential immune-related biomarker in oral squamous cell carcinoma (OSCC). OncoTargets and therapy, 14, 1275.

Liang, Y., & Peng, Y. (2021). Gene body methylation facilitates the transcription of CTSG via antisense lncRNA AL136018. 1 in dermatomyositic myoideum. Cell Biology International, 45(2), 456-462.

Mamoor, S. (2020). Cathepsin G, encoded by CTSG is differentially expressed in metastatic breast cancer, both in metastases to the brain and to the lymph nodes.

Kusumaningrum, N., Oh, J. H., Lee, D. H., Shin, C. Y., Jang, J. H., Kim, Y. K., & Chung, J. H. (2019). Topical treatment with a cathepsin G inhibitor, β‐keto‐phosphonic acid, blocks ultraviolet irradiation‐induced basement membrane damage in hairless mouse skin. Photodermatology, Photoimmunology & Photomedicine, 35(3), 148-156.

Pérez-Is, L., Ocaña, M. G., Montes, A. H., Carton, J. A., Álvarez, V., Meana, Á., ... & Asensi, V. (2019). The N125S polymorphism in the cathepsin G gene (rs45567233) is associated with susceptibility to osteomyelitis in a Spanish population. PloS one, 14(10), e0220022.

Aghdassi, A. A., John, D. S., Sendler, M., Storck, C., van den Brandt, C., Krüger, B., ... & Lerch, M. M. (2019). Absence of the neutrophil serine protease cathepsin G decreases neutrophil granulocyte infiltration but does not change the severity of acute pancreatitis. Scientific reports, 9(1), 1-10.

Schoenherr, C., Wohlan, K., Dallmann, I., Pich, A., Hegermann, J., Ganser, A., ... & Eder, M. (2019). Stable depletion of RUNX1-ETO in Kasumi-1 cells induces expression and enhanced proteolytic activity of Cathepsin G and Neutrophil Elastase. Plos one, 14(12), e0225977.

Siming, G. A. O., Honglin, Z. H. U., Xiaoxia, Z. U. O., & Hui, L. U. O. (2018). Cathepsin G and its role in inflammation and autoimmune diseases. Archives of rheumatology, 33(4), 498.

Gao, S., Zhu, H., Yang, H., Zhang, H., Li, Q., & Luo, H. (2017). The role and mechanism of cathepsin G in dermatomyositis. Biomedicine & Pharmacotherapy, 94, 697-704.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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