CTSG
CTSG (Cathepsin G) is a Protein Coding gene. Diseases associated with CTSG include Vasculitis and Cutaneous Mastocytosis. Among its related pathways are Peptide hormone metabolism and Innate Immune System. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity and peptidase activity. An important paralog of this gene is GZMB.
Full Name
Cathepsin G
Function
Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial activity is inhibited by LPS from P.aeruginosa, Z-Gly-Leu-Phe-CH2Cl and phenylmethylsulfonyl fluoride.
Biological Process
Angiotensin maturation Source: Reactome
Antibacterial humoral response Source: UniProtKB
Antimicrobial humoral response Source: Reactome
Cellular protein metabolic process Source: Reactome
Cellular response to lipopolysaccharide Source: UniProtKB
Cytokine-mediated signaling pathway Source: Reactome
Defense response to fungus Source: Ensembl
Defense response to Gram-negative bacterium Source: UniProtKB
Extracellular matrix disassembly Source: Reactome
Immune response Source: ProtInc
Negative regulation by symbiont of host apoptotic process Source: Reactome
Neutrophil degranulation Source: Reactome
Neutrophil-mediated killing of gram-positive bacterium Source: Ensembl
Positive regulation of immune response Source: Ensembl
Protein phosphorylation Source: CACAO
Proteolysis Source: UniProtKB
Purinergic nucleotide receptor signaling pathway Source: Reactome
Antibacterial humoral response Source: UniProtKB
Antimicrobial humoral response Source: Reactome
Cellular protein metabolic process Source: Reactome
Cellular response to lipopolysaccharide Source: UniProtKB
Cytokine-mediated signaling pathway Source: Reactome
Defense response to fungus Source: Ensembl
Defense response to Gram-negative bacterium Source: UniProtKB
Extracellular matrix disassembly Source: Reactome
Immune response Source: ProtInc
Negative regulation by symbiont of host apoptotic process Source: Reactome
Neutrophil degranulation Source: Reactome
Neutrophil-mediated killing of gram-positive bacterium Source: Ensembl
Positive regulation of immune response Source: Ensembl
Protein phosphorylation Source: CACAO
Proteolysis Source: UniProtKB
Purinergic nucleotide receptor signaling pathway Source: Reactome
Cellular Location
Cell surface
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Anti-CTSG antibodies
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CompareTarget: CTSG
Sensitivity: 0.01 ng/mL
Detection Range: 0.02-4.5 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: Ctsg
Sensitivity: 0.106 ng/mL
Detection Range: 0.2-60 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Mouse
Assay Type: Sandwich
Reactivity: Mouse
Target: Ctsg
Sensitivity: 0.0095 ng/mL
Detection Range: 0.02-4.5 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Rat
Assay Type: Sandwich
Reactivity: Rat
Target: CTSG
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBCNC-479
Application*: WB, E
Target: CTSG
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYC-2449
Application*: E, IF
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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