Rat Ctsg ELISA Kit (V2LY-0626-LY1599)

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Tested Data
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity
0.0095 ng/mL
Detection Range
0.02-4.5 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Rat
Assay Type
Sandwich
Reactivity
Rat
Assay Time
1.5 h
Molecule Mass
2.9 kDa
Components
  • Pre-coated ELISA plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
Cathepsin G
Function
Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial activity is inhibited by LPS from P.aeruginosa, Z-Gly-Leu-Phe-CH2Cl and phenylmethylsulfonyl fluoride.
Biological Process
Angiotensin maturation Source: Reactome
Antibacterial humoral response Source: UniProtKB
Antimicrobial humoral response Source: Reactome
Cellular protein metabolic process Source: Reactome
Cellular response to lipopolysaccharide Source: UniProtKB
Cytokine-mediated signaling pathway Source: Reactome
Defense response to fungus Source: Ensembl
Defense response to Gram-negative bacterium Source: UniProtKB
Extracellular matrix disassembly Source: Reactome
Immune response Source: ProtInc
Negative regulation by symbiont of host apoptotic process Source: Reactome
Neutrophil degranulation Source: Reactome
Neutrophil-mediated killing of gram-positive bacterium Source: Ensembl
Positive regulation of immune response Source: Ensembl
Protein phosphorylation Source: CACAO
Proteolysis Source: UniProtKB
Purinergic nucleotide receptor signaling pathway Source: Reactome
Cellular Location
Cell surface

Huang, G. Z., Wu, Q. Q., Zheng, Z. N., Shao, T. R., Li, F., Lu, X. Y., ... & Lv, X. Z. (2021). Bioinformatics analyses indicate that Cathepsin G (CTSG) is a potential immune-related biomarker in oral squamous cell carcinoma (OSCC). OncoTargets and therapy, 14, 1275.

Liang, Y., & Peng, Y. (2021). Gene body methylation facilitates the transcription of CTSG via antisense lncRNA AL136018. 1 in dermatomyositic myoideum. Cell Biology International, 45(2), 456-462.

Mamoor, S. (2020). Cathepsin G, encoded by CTSG is differentially expressed in metastatic breast cancer, both in metastases to the brain and to the lymph nodes.

Kusumaningrum, N., Oh, J. H., Lee, D. H., Shin, C. Y., Jang, J. H., Kim, Y. K., & Chung, J. H. (2019). Topical treatment with a cathepsin G inhibitor, β‐keto‐phosphonic acid, blocks ultraviolet irradiation‐induced basement membrane damage in hairless mouse skin. Photodermatology, Photoimmunology & Photomedicine, 35(3), 148-156.

Pérez-Is, L., Ocaña, M. G., Montes, A. H., Carton, J. A., Álvarez, V., Meana, Á., ... & Asensi, V. (2019). The N125S polymorphism in the cathepsin G gene (rs45567233) is associated with susceptibility to osteomyelitis in a Spanish population. PloS one, 14(10), e0220022.

Aghdassi, A. A., John, D. S., Sendler, M., Storck, C., van den Brandt, C., Krüger, B., ... & Lerch, M. M. (2019). Absence of the neutrophil serine protease cathepsin G decreases neutrophil granulocyte infiltration but does not change the severity of acute pancreatitis. Scientific reports, 9(1), 1-10.

Schoenherr, C., Wohlan, K., Dallmann, I., Pich, A., Hegermann, J., Ganser, A., ... & Eder, M. (2019). Stable depletion of RUNX1-ETO in Kasumi-1 cells induces expression and enhanced proteolytic activity of Cathepsin G and Neutrophil Elastase. Plos one, 14(12), e0225977.

Siming, G. A. O., Honglin, Z. H. U., Xiaoxia, Z. U. O., & Hui, L. U. O. (2018). Cathepsin G and its role in inflammation and autoimmune diseases. Archives of rheumatology, 33(4), 498.

Gao, S., Zhu, H., Yang, H., Zhang, H., Li, Q., & Luo, H. (2017). The role and mechanism of cathepsin G in dermatomyositis. Biomedicine & Pharmacotherapy, 94, 697-704.

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For research use only. Not intended for any clinical use.

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