Sign in or Register   Sign in or Register
  |  

Rabbit Anti-CTSH Recombinant Antibody (EPR7602) (CBMAB-1490-CN)

This product is a rabbit antibody that recognizes CTSH of human. The antibody EPR7602 can be used for immunoassay techniques such as: IF, IHC-P, WB.
See all CTSH antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Rat
Clone
EPR7602
Antibody Isotype
IgG
Application
IF, IHC-P, WB

Basic Information

Immunogen
Synthetic peptide corresponding to residues in Human Cathepsin H.
Specificity
Human, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
49% PBS, 50% Glycerol, 0.05% BSA, pH 7.2
Preservative
0.01% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cathepsin H
Introduction
The protein encoded by this gene is a lysosomal cysteine proteinase important in the overall degradation of lysosomal proteins. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. The protein, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Increased expression of this gene has been correlated with malignant progression of prostate tumors.
Entrez Gene ID
Human1512
Rat25425
UniProt ID
HumanP09668
RatP00786
Alternative Names
ACC4; ACC5; CPSB; ACC-4; ACC-5
Function
Important for the overall degradation of proteins in lysosomes.
Biological Process
Adaptive immune response Source: UniProtKB
Antigen processing and presentation Source: UniProtKB
Bradykinin catabolic process Source: UniProtKB
Cellular protein metabolic process Source: Reactome
Cellular response to thyroid hormone stimulus Source: UniProtKB
Dichotomous subdivision of terminal units involved in lung branching Source: UniProtKB
ERK1 and ERK2 cascade Source: UniProtKB
Immune response-regulating signaling pathway Source: UniProtKB
Membrane protein proteolysis Source: UniProtKB
Metanephros development Source: UniProtKB
Negative regulation of apoptotic process Source: UniProtKB
Neuropeptide catabolic process Source: UniProtKB
Neutrophil degranulation Source: Reactome
Positive regulation of angiogenesis Source: UniProtKB
Positive regulation of cell migration Source: UniProtKB
Positive regulation of cell population proliferation Source: UniProtKB
Positive regulation of epithelial cell migration Source: UniProtKB
Positive regulation of gene expression Source: UniProtKB
Positive regulation of peptidase activity Source: UniProtKB
Protein destabilization Source: UniProtKB
Proteolysis Source: UniProtKB
Proteolysis involved in cellular protein catabolic process Source: GO_Central
Response to retinoic acid Source: UniProtKB
Surfactant homeostasis Source: UniProtKB
T cell mediated cytotoxicity Source: UniProtKB
Zymogen activation Source: UniProtKB
Cellular Location
Lysosome

Peng, P., Chen, J. Y., Zheng, K., Hu, C. H., & Han, Y. T. (2021). Favorable Prognostic Impact of Cathepsin H (CTSH) High Expression in Thyroid Carcinoma. International Journal of General Medicine, 14, 5287.

Ye, J., Stefan-Lifshitz, M., & Tomer, Y. (2021). Genetic and environmental factors regulate the type 1 diabetes gene CTSH via differential DNA methylation. Journal of Biological Chemistry, 296.

Fløyel, T., Mirza, A. H., Kaur, S., Frørup, C., Yarani, R., Størling, J., & Pociot, F. (2020). The Rac2 GTPase contributes to cathepsin H-mediated protection against cytokine-induced apoptosis in insulin-secreting cells. Molecular and Cellular Endocrinology, 518, 110993.

Oda, K., Luo, Y., Yoshihara, A., Ishido, Y., Sekihata, K., Usukura, K., ... & Suzuki, K. (2017). Follicular thyroglobulin induces cathepsin H expression and activity in thyrocytes. Biochemical and biophysical research communications, 483(1), 541-546.

Naeem, A. S., Tommasi, C., Cole, C., Brown, S. J., Zhu, Y., Way, B., ... & O'Shaughnessy, R. F. (2017). A mechanistic target of rapamycin complex 1/2 (mTORC1)/V-Akt murine thymoma viral oncogene homolog 1 (AKT1)/cathepsin H axis controls filaggrin expression and processing in skin, a novel mechanism for skin barrier disruption in patients with atopic dermatitis. Journal of Allergy and Clinical Immunology, 139(4), 1228-1241.

Yang, Z., Liu, Y., Qin, L., Wu, P., Xia, Z., Luo, M., ... & Han, Y. P. (2017). Cathepsin H–mediated degradation of HDAC4 for matrix metalloproteinase expression in hepatic stellate cells: implications of epigenetic suppression of matrix metalloproteinases in fibrosis through stabilization of class IIa histone deacetylases. The American journal of pathology, 187(4), 781-797.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Rabbit Anti-CTSH Recombinant Antibody (EPR7602)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare