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Mouse Anti-CTSK Recombinant Antibody (CAP600) (CBMAB-AP1783LY)


See all CTSK antibodies

Summary

Host Animal
Mouse
Specificity
Human, Pig, Rat
Clone
CAP600
Antibody Isotype
IgG
Application
ICC, IHC, IP, WB

Basic Information

Immunogen
Ala115~Met329
Specificity
Human, Pig, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Cathepsin K
Introduction
CTSK (Cathepsin K) is a Protein Coding gene. Diseases associated with CTSK include Pycnodysostosis and Endosteal Hyperostosis, Autosomal Dominant. Among its related pathways are RANK Signaling in Osteoclasts and Innate Immune System. Gene Ontology (GO) annotations related to this gene include cysteine-type endopeptidase activity and collagen binding. An important paralog of this gene is CTSS.
Entrez Gene ID
Human1513
Pig397569
Rat29175
UniProt ID
HumanP43235
PigQ9GLE3
RatO35186
Alternative Names
Cathepsin K; Cathepsin O2; EC 3.4.22.38; Cathepsin O; Cathepsin X; CTSO2; CTSO; Cathepsin K (Pycnodysostosis);
Function
Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (PubMed:11082042).
Biological Process
Autophagy of mitochondrion Source: ParkinsonsUK-UCL
Collagen catabolic process Source: BHF-UCL
Extracellular matrix disassembly Source: Reactome
Immune response Source: GO_Central
Proteolysis Source: ProtInc
Proteolysis involved in cellular protein catabolic process Source: UniProtKB
Regulation of keratinocyte differentiation Source: Reactome
Thyroid hormone generation Source: UniProtKB
Toll-like receptor signaling pathway Source: Reactome
Cellular Location
Lysosome; Apical cell membrane; Secreted. Localizes to the lumen of thyroid follicles and to the apical membrane of thyroid epithelial cells.
Involvement in disease
Pycnodysostosis (PKND):
A rare autosomal recessive bone disorder characterized by deformity of the skull, maxilla and phalanges, osteosclerosis, and fragility of bone.

Heo, S. C., Kim, Y. N., Choi, Y., Joo, J. Y., Hwang, J. J., Bae, M. K., & Kim, H. J. (2021). Elevated expression of cathepsin K in periodontal ligament fibroblast by inflammatory cytokines accelerates osteoclastogenesis via paracrine mechanism in periodontal disease. International Journal of Molecular Sciences, 22(2), 695.

Zhang, W., Dong, Z., Li, D., Li, B., Liu, Y., Zheng, X., ... & Xue, Y. (2021). Cathepsin K deficiency promotes alveolar bone regeneration by promoting jaw bone marrow mesenchymal stem cells proliferation and differentiation via glycolysis pathway. Cell proliferation, 54(7), e13058.

Dauth, S., Rakov, H., Sîrbulescu, R. F., Ilieş, I., Weber, J., Batbajar Dugershaw, B., ... & Brix, K. (2020). Function of Cathepsin K in the central nervous system of male mice is independent of its role in the thyroid gland. Cellular and Molecular Neurobiology, 40(5), 695-710.

Feng, H., Xing, W., Han, Y., Sun, J., Kong, M., Gao, B., ... & Zou, W. (2020). Tendon-derived cathepsin K–expressing progenitor cells activate Hedgehog signaling to drive heterotopic ossification. The Journal of clinical investigation, 130(12), 6354-6365.

Li, R., Zhou, R., Wang, H., Li, W., Pan, M., Yao, X., ... & Zhao, L. (2019). Gut microbiota-stimulated cathepsin K secretion mediates TLR4-dependent M2 macrophage polarization and promotes tumor metastasis in colorectal cancer. Cell Death & Differentiation, 26(11), 2447-2463.

Pang, M., Rodríguez‐Gonzalez, M., Hernandez, M., Recinos, C. C., Seldeen, K. L., & Troen, B. R. (2019). AP‐1 and Mitf interact with NFATc1 to stimulate cathepsin K promoter activity in osteoclast precursors. Journal of cellular biochemistry, 120(8), 12382-12392.

Lotinun, S., Ishihara, Y., Nagano, K., Kiviranta, R., Carpentier, V. T., Neff, L., ... & Baron, R. (2019). Cathepsin K–deficient osteocytes prevent lactation-induced bone loss and parathyroid hormone suppression. The Journal of clinical investigation, 129(8), 3058-3071.

Leusink, F. K., Koudounarakis, E., Frank, M. H., Koole, R., van Diest, P. J., & Willems, S. M. (2018). Cathepsin K associates with lymph node metastasis and poor prognosis in oral squamous cell carcinoma. Bmc Cancer, 18(1), 1-9.

Fan, X., Wang, C., Song, X., Liu, H., Li, X., & Zhang, Y. (2018). Elevated Cathepsin K potentiates metastasis of epithelial ovarian cancer. Histology and Histopathology, 33(7), 673-680.

Walia, B., Lingenheld, E., Duong, L., Sanjay, A., & Drissi, H. (2018). A novel role for cathepsin K in periosteal osteoclast precursors during fracture repair. Annals of the New York Academy of Sciences, 1415(1), 57-68.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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