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Rabbit Anti-CTSS Recombinant Antibody (EPR5128) (CBMAB-1495-CN)

This product is a rabbit antibody that recognizes CTSS of human. The antibody EPR5128 can be used for immunoassay techniques such as: IF, WB, IHC-P.
See all CTSS antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
EPR5128
Antibody Isotype
IgG
Application
IF, WB, IHC-P

Basic Information

Immunogen
Synthetic peptide corresponding to residues near the C terminus of Human Cathepsin S (UniProt ID: P25774)
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50% Glycerol, 0.05% BSA, pH 7.4
Preservative
0.01% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cathepsin S
Introduction
The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. The encoded protein can function as an elastase over a broad pH range in alveolar macrophages. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L.
Entrez Gene ID
1520
UniProt ID
P25774
Alternative Names
cathepsin S; EC 3.4.22.27
Function
Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules and MHC class II antigen presentation (PubMed:30612035).

The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L.
Biological Process
Adaptive immune response Source: UniProtKB
Antigen processing and presentation Source: UniProtKB
Antigen processing and presentation of exogenous peptide antigen via MHC class II Source: UniProtKB
Antigen processing and presentation of peptide antigen Source: CACAO
Basement membrane disassembly Source: BHF-UCL
Cellular response to thyroid hormone stimulus Source: UniProtKB
Collagen catabolic process Source: BHF-UCL
Extracellular matrix disassembly Source: Reactome
Immune response Source: GO_Central
Neutrophil degranulation Source: Reactome
Positive regulation of cation channel activity Source: CACAO
Protein processing Source: CACAO
Proteolysis Source: CAFA
Proteolysis involved in cellular protein catabolic process Source: BHF-UCL
Response to acidic pH Source: CACAO
Toll-like receptor signaling pathway Source: Reactome
Cellular Location
Secreted; Lysosome; Phagosome

Yoo, Y., Choi, E., Kim, Y., Cha, Y., Um, E., Kim, Y., ... & Lee, Y. S. (2022). Therapeutic potential of targeting cathepsin S in pulmonary fibrosis. Biomedicine & Pharmacotherapy, 145, 112245.

Bararia, D., Hildebrand, J. A., Stolz, S., Haebe, S., Alig, S., Trevisani, C. P., ... & Weigert, O. (2020). Cathepsin S alterations induce a tumor-promoting immune microenvironment in follicular lymphoma. Cell reports, 31(5), 107522.

Brown, R., Nath, S., Lora, A., Samaha, G., Elgamal, Z., Kaiser, R., ... & Geraghty, P. (2020). Cathepsin S: investigating an old player in lung disease pathogenesis, comorbidities, and potential therapeutics. Respiratory Research, 21(1), 1-17.

Ni, H., Xu, S., Chen, H., & Dai, Q. (2020). Nicotine modulates CTSS (cathepsin S) synthesis and secretion through regulating the autophagy-lysosomal machinery in atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology, 40(9), 2054-2069.

Lai, C. H., Chang, J. Y., Wang, K. C., Lee, F. T., Wu, H. L., & Cheng, T. L. (2020). Pharmacological inhibition of cathepsin S suppresses abdominal aortic aneurysm in mice. European Journal of Vascular and Endovascular Surgery, 59(6), 990-999.

Doherty, D. F., Nath, S., Poon, J., Foronjy, R. F., Ohlmeyer, M., Dabo, A. J., ... & Geraghty, P. (2019). Protein phosphatase 2A reduces cigarette smoke–induced cathepsin S and loss of lung function. American journal of respiratory and critical care medicine, 200(1), 51-62.

Kim, S., Jin, H., Seo, H. R., Lee, H. J., & Lee, Y. S. (2019). Regulating BRCA1 protein stability by cathepsin S-mediated ubiquitin degradation. Cell Death & Differentiation, 26(5), 812-825.

Wilkinson, R. D., Burden, R. E., McDowell, S. H., McArt, D. G., McQuaid, S., Bingham, V., ... & Scott, C. J. (2019). A novel role for cathepsin S as a potential biomarker in triple negative breast cancer. Journal of Oncology, 2019.

Edman, M. C., Janga, S. R., Meng, Z., Bechtold, M., Chen, A. F., Kim, C., ... & Hamm-Alvarez, S. F. (2018). Increased Cathepsin S activity associated with decreased protease inhibitory capacity contributes to altered tear proteins in Sjögren’s Syndrome patients. Scientific reports, 8(1), 1-12.

Tan, J., Qian, X., Song, B., An, X., Cai, T., Zuo, Z., ... & Li, H. (2018). Integrated bioinformatics analysis reveals that the expression of cathepsin S is associated with lymph node metastasis and poor prognosis in papillary thyroid cancer. Oncology reports, 40(1), 111-122.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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