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Mouse Anti-CTSV Recombinant Antibody (182016) (CBMAB-C3448-LY)

This product is antibody recognizes CTSV. The antibody 182016 immunoassay techniques such as: WB, IHC, IP.
See all CTSV antibodies
Published Data
Fig.1 Active cathepsin V variant in the nucleus of HTh74 cells.
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Fig.2 Nuclear localization of cathepsin V in HTh74 cells.
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Fig.3 Cardiac morphology and histology of the Tg(K14-CTSL2) mouse.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
182016
Antibody Isotype
IgG1
Application
WB, IHC, IP

Basic Information

Immunogen
Mouse myeloma cell line NS0-derived recombinant human Cathepsin V, Accession # O60911
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Cathepsin V
Introduction
CTSV (Cathepsin V) is a Protein Coding gene. Among its related pathways are Innate Immune System and Matrix Metalloproteinases. Gene Ontology (GO) annotations related to this gene include protein complex binding and cysteine-type endopeptidase activity. An important paralog of this gene is CTSL.
Entrez Gene ID
1515
UniProt ID
O60911
Alternative Names
Cathepsin V; Cathepsin L2; Cathepsin U; CTSL2; CATL2; CTSU; Cathepsin L2, Preproprotein; EC 3.4.22.43; EC 3.4.22;
Function
Cysteine protease. May have an important role in corneal physiology.
Biological Process
Antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
Extracellular matrix disassembly Source: Reactome
Immune response Source: GO_Central
Proteolysis involved in cellular protein catabolic process Source: GO_Central
Regulation of keratinocyte differentiation Source: Reactome
Cellular Location
Lysosome

Lin, C. L., Hung, T. W., Ying, T. H., Lin, C. J., Hsieh, Y. H., & Chen, C. M. (2020). Praeruptorin B mitigates the metastatic ability of human renal carcinoma cells through targeting CTSC and CTSV expression. International journal of molecular sciences, 21(8), 2919.

Toss, M., Miligy, I., Gorringe, K., Mittal, K., Aneja, R., Ellis, I., ... & Rakha, E. (2020). Prognostic significance of cathepsin V (CTSV/CTSL2) in breast ductal carcinoma in situ. Journal of Clinical Pathology, 73(2), 76-82.

Wang, C. H., Wang, L. K., Wu, C. C., Chen, M. L., Kuo, C. Y., Shyu, R. Y., & Tsai, F. M. (2020). Cathepsin V Mediates the Tazarotene-induced Gene 1-induced Reduction in Invasion in Colorectal Cancer Cells. Cell Biochemistry and Biophysics, 78(4), 483-494.

Matsukawa, S., Sumigama, S., Kotani, T., Wang, J., Miki, R., Moriyama, Y., ... & Kikkawa, F. (2019). Possible association between cathepsin V and the development of placenta accreta spectrum disorders. Gynecologic and Obstetric Investigation, 84(4), 396-406.

Homma, T., Kageyama, S., Nishikawa, A., & Nagata, K. (2018). Melanosome degradation in epidermal keratinocytes related to lysosomal protease cathepsin V. Biochemical and biophysical research communications, 500(2), 339-343.

Podvin, S., Wojnicz, A., & Hook, V. (2018). Human brain gene expression profiles of the cathepsin V and cathepsin L cysteine proteases, with the PC1/3 and PC2 serine proteases, involved in neuropeptide production. Heliyon, 4(7), e00673.

Huang, K., Gao, L., Yang, M., Wang, J., Wang, Z., Wang, L., ... & Li, H. (2017). Exogenous cathepsin V protein protects human cardiomyocytes HCM from angiotensin Ⅱ-Induced hypertrophy. The International Journal of Biochemistry & Cell Biology, 89, 6-15.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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