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Rabbit Anti-CTSV Recombinant Antibody (EPR8011) (CBMAB-1497-CN)

This product is a rabbit antibody that recognizes CTSV of human. The antibody EPR8011 can be used for immunoassay techniques such as: FC, IF, IHC-P, WB.
See all CTSV antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
EPR8011
Antibody Isotype
IgG
Application
FC, IF, IHC-P, WB

Basic Information

Immunogen
Synthetic peptide corresponding to Human Cathepsin L/V/K/H aa. 100-200.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
59% PBS, 40% Glycerol, 0.05% BSA, pH 7.2
Preservative
0.01% Sodium azide
Concentration
0.093 - 0.107 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cathepsin V
Introduction
The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may play an important role in corneal physiology. This gene is expressed in colorectal and breast carcinomas but not in normal colon, mammary gland, or peritumoral tissues, suggesting a possible role for this gene in tumor processes. The protein may have an important role in corneal physiology.
Entrez Gene ID
Human1515
Mouse110307838
Rat103751610
UniProt ID
HumanO60911
MouseA0A6P5QP33
Alternative Names
CTSU; CATL2; CTSL2
Function
Cysteine protease. May have an important role in corneal physiology.
Biological Process
Antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
Extracellular matrix disassembly Source: Reactome
Immune response Source: GO_Central
Proteolysis involved in cellular protein catabolic process Source: GO_Central
Regulation of keratinocyte differentiation Source: Reactome
Cellular Location
Lysosome

Lin, C. L., Hung, T. W., Ying, T. H., Lin, C. J., Hsieh, Y. H., & Chen, C. M. (2020). Praeruptorin B mitigates the metastatic ability of human renal carcinoma cells through targeting CTSC and CTSV expression. International journal of molecular sciences, 21(8), 2919.

Toss, M., Miligy, I., Gorringe, K., Mittal, K., Aneja, R., Ellis, I., ... & Rakha, E. (2020). Prognostic significance of cathepsin V (CTSV/CTSL2) in breast ductal carcinoma in situ. Journal of Clinical Pathology, 73(2), 76-82.

Wang, C. H., Wang, L. K., Wu, C. C., Chen, M. L., Kuo, C. Y., Shyu, R. Y., & Tsai, F. M. (2020). Cathepsin V Mediates the Tazarotene-induced Gene 1-induced Reduction in Invasion in Colorectal Cancer Cells. Cell Biochemistry and Biophysics, 78(4), 483-494.

Matsukawa, S., Sumigama, S., Kotani, T., Wang, J., Miki, R., Moriyama, Y., ... & Kikkawa, F. (2019). Possible association between cathepsin V and the development of placenta accreta spectrum disorders. Gynecologic and Obstetric Investigation, 84(4), 396-406.

Homma, T., Kageyama, S., Nishikawa, A., & Nagata, K. (2018). Melanosome degradation in epidermal keratinocytes related to lysosomal protease cathepsin V. Biochemical and biophysical research communications, 500(2), 339-343.

Podvin, S., Wojnicz, A., & Hook, V. (2018). Human brain gene expression profiles of the cathepsin V and cathepsin L cysteine proteases, with the PC1/3 and PC2 serine proteases, involved in neuropeptide production. Heliyon, 4(7), e00673.

Huang, K., Gao, L., Yang, M., Wang, J., Wang, Z., Wang, L., ... & Li, H. (2017). Exogenous cathepsin V protein protects human cardiomyocytes HCM from angiotensin Ⅱ-Induced hypertrophy. The International Journal of Biochemistry & Cell Biology, 89, 6-15.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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