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Mouse Anti-CTSZ Recombinant Antibody (MM0134-7L16) (CBMAB-C11338-LY)

The product is antibody recognizes CTSZ. The antibody MM0134-7L16 immunoassay techniques such as: WB.
See all CTSZ antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
MM0134-7L16
Antibody Isotype
IgG2
Application
WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.5 mg/mL
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Cathepsin Z
Introduction
CTSZ (Cathepsin Z) is a Protein Coding gene. Diseases associated with CTSZ include Dacryoadenitis. Among its related pathways are Peptide hormone metabolism and Clathrin derived vesicle budding. Gene Ontology (GO) annotations related to this gene include cysteine-type peptidase activity. An important paralog of this gene is CTSC.
Entrez Gene ID
1522
UniProt ID
Q9UBR2
Alternative Names
Cathepsin Z; Cathepsin X; Cysteine-Type Carboxypeptidase; Lysosomal Carboxypeptidase B; Carboxypeptidase LB; Cathepsin IV; Cathepsin B2;
Function
Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity (PubMed:10504234).

Capable of producing kinin potentiating peptides (By similarity).
Biological Process
Angiotensin maturation Source: Reactome
COPII vesicle coating Source: Reactome
Endoplasmic reticulum to Golgi vesicle-mediated transport Source: Reactome
Negative regulation of plasminogen activation Source: CAFA
Negative regulation of protein binding Source: CAFA
Neutrophil degranulation Source: Reactome
Proteolysis Source: CAFA
Proteolysis involved in cellular protein catabolic process Source: GO_Central
Regulation of neuron death Source: CAFA
Cellular Location
Lysosome

Batista, A. A. S., Franco, B. M., Perez, M. M., Pereira, E. G., Rodrigues, T., Wroclawski, M. L., ... & Suarez, E. R. (2021). Decreased levels of cathepsin Z mRNA expressed by immune blood cells: diagnostic and prognostic implications in prostate cancer. Brazilian Journal of Medical and Biological Research, 54.

Choi, K. M., Joo, M. S., Cho, D. H., Han, H. J., Kim, M. S., Cho, M. Y., ... & Park, C. I. (2019). Functional analysis and gene expression profiling of extracellular cathepsin Z in red sea bream, Pagrus major. Fish & Shellfish Immunology, 93, 208-215.

Lewis, M. S., Danelishvili, L., Rose, S. J., & Bermudez, L. E. (2019). MAV_4644 Interaction with the host cathepsin Z protects Mycobacterium avium subsp. hominissuis from rapid macrophage killing. Microorganisms, 7(5), 144.

Cai, X., Gao, C., Song, H., Yang, N., Fu, Q., Tan, F., & Li, C. (2019). Characterization, expression profiling and functional characterization of cathepsin Z (CTSZ) in turbot (Scophthalmus maximus L.). Fish & Shellfish Immunology, 84, 599-608.

Fang, Y., Zhang, D., Hu, T., Zhao, H., Zhao, X., Lou, Z., ... & Ye, L. C. (2019). KMT2A histone methyltransferase contributes to colorectal cancer development by promoting cathepsin Z transcriptional activation. Cancer medicine, 8(7), 3544-3552.

Aiba, Y., Harada, K., Ito, M., Suematsu, T., Aishima, S., Hitomi, Y., ... & Nakamura, M. (2018). Increased expression and altered localization of cathepsin Z are associated with progression to jaundice stage in primary biliary cholangitis. Scientific reports, 8(1), 1-11.

Li, W., Yu, X., Ma, X., Xie, L., Xia, Z., Liu, L., ... & Liu, H. (2018). Deguelin attenuates non-small cell lung cancer cell metastasis through inhibiting the CtsZ/FAK signaling pathway. Cellular Signalling, 50, 131-141.

Allan, E. R., Campden, R. I., Ewanchuk, B. W., Tailor, P., Balce, D. R., McKenna, N. T., ... & Yates, R. M. (2017). A role for cathepsin Z in neuroinflammation provides mechanistic support for an epigenetic risk factor in multiple sclerosis. Journal of Neuroinflammation, 14(1), 1-11.

Godahewa, G. I., Perera, N. C. N., Lee, S., Kim, M. J., & Lee, J. (2017). A cysteine protease (cathepsin Z) from disk abalone, Haliotis discus discus: genomic characterization and transcriptional profiling during bacterial infections. Gene, 627, 500-507.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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