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Mouse Anti-CUEDC2 Recombinant Antibody (CBWJC-3448) (CBMAB-C4678WJ)

This product is a Mouse antibody that recognizes CUEDC2. This antibody CBWJC-3448 can be used for immunoassay techniques such as: WB.
See all CUEDC2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBWJC-3448
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Full length human recombinant protein of human CUEDC2 (NP_076945) produced in E.coli
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS (PH 7.3), 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
CUE domain containing 2
Introduction
CUEDC2 (CUE Domain Containing 2) is a Protein Coding gene. Among its related pathways are DNA Damage.
Entrez Gene ID
79004
UniProt ID
Q9H467
Alternative Names
CUE Domain Containing 2; C10orf66; Chromosome 10 Open Reading Frame 66; CUE Domain-Containing Protein 2; BA18I14.5;
Function
Down-regulates ESR1 protein levels through the ubiquitination-proteasome pathway, regardless of the presence of 17 beta-estradiol. Also involved in 17 beta-estradiol-induced ESR1 degradation. Controls PGR protein levels through a similar mechanism.
Biological Process
Negative regulation of cytokine production involved in inflammatory response Source: MGI
Negative regulation of macrophage cytokine production Source: MGI
Cellular Location
Nucleus; Cytoplasm
Involvement in disease
May predict the clinical outcome of tamoxifen therapy of breast cancer patients. Patients with tumors that highly express CUEDC2 do not respond to tamoxifen treatment as effectively as those with tumors with low expression.

Huang, Y., Xiao, X., Xiao, H., Hu, Z., & Tan, F. (2021). CUEDC2 ablation enhances the efficacy of mesenchymal stem cells in ameliorating cerebral ischemia/reperfusion insult. Aging (Albany NY), 13(3), 4335.

Xu, S., Huang, S., Li, D., Zou, Q., Yuan, Y., & Yang, Z. (2020). Comparison of ADAM19 and CUEDC2 expression in EHCC and their clinicopathological significance. Biomarkers in Medicine, 14(16), 1573-1584.

Kim, J. W., Oh, S. H., Lee, M. N., Song, J. H., Jeong, B. C., Yang, J. W., ... & Koh, J. T. (2020). CUEDC2 controls osteoblast differentiation and bone formation via SOCS3–STAT3 pathway. Cell death & disease, 11(5), 1-13.

Hu, L. Y., Ning, J., Li, A. L., Li, Y. L., & You, Y. Q. (2020). Expression of CUEDC2 in serous ovarian carcinoma and correlation with clinical characters. Medical Journal of Chinese People's Liberation Army, 45(12), 1265-1269.

Xiao, J. B., Leng, A. M., Zhang, Y. Q., Wen, Z., He, J., & Ye, G. N. (2019). CUEDC2: multifunctional roles in carcinogenesis. Front Biosci (Landmark Ed), 24, 935-946.

Hu, S., Hu, Z., Li, S., He, C., Wu, Y., Teng, D., ... & Du, X. (2019). Expression of CUEDC2 in colorectal cancer with different invasion and migration abilities. Journal of International Medical Research, 47(2), 905-914.

Wang, A., Li, J., Zhou, T., Li, T., Cai, H., Shi, H., & Liu, A. (2019). CUEDC2 contributes to cisplatin-based chemotherapy resistance in ovarian serious carcinoma by regulating p38 MAPK signaling. Journal of Cancer, 10(8), 1800.

Wu, Q. Y., Zhu, Y. Y., Liu, Y., Wei, F., Tong, Y. X., Cao, J., ... & Xu, K. L. (2018). CUEDC2, a novel interacting partner of the SOCS1 protein, plays important roles in the leukaemogenesis of acute myeloid leukaemia. Cell death & disease, 9(7), 1-15.

Li, F., Tang, C., Jin, D., Guan, L., Wu, Y., Liu, X., ... & Gao, D. (2017). CUEDC2 suppresses glioma tumorigenicity by inhibiting the activation of STAT3 and NF-κB signaling pathway. International Journal of Oncology, 51(1), 115-127.

Zhong, X., Tian, S., Zhang, X., Diao, X., Dong, F., Yang, J., ... & Gao, P. (2017). CUE domain‐containing protein 2 promotes the Warburg effect and tumorigenesis. EMBO reports, 18(5), 809-825.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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