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Mouse Anti-CUX2 Recombinant Antibody (2H8) (CBMAB-C5305-LY)

This product is antibody recognizes CUX2. The antibody 2H8 immunoassay techniques such as: ELISA, WB.
See all CUX2 antibodies
Published Data
Fig. 1 Slides were immunohistochemically stained with CUX2.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
2H8
Antibody Isotype
IgG1, κ
Application
ELISA, WB

Basic Information

Immunogen
CUX2 (NP_056082.1, 121 a.a. ~ 220 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: FDPSGQPRRD LHTSWKRNPE LLSPKEQREG TSPAGPTLTE GSRLPGIPGK ALLTETLLQR NEAEKQKGLQ EVQITLAARL GEAEEKIKVL HSALKATQAE
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
cut-like homeobox 2
Introduction
CUX2 (Cut Like Homeobox 2) is a Protein Coding gene. Diseases associated with CUX2 include Fiedler's Myocarditis. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding and RNA polymerase II regulatory region sequence-specific DNA binding. An important paralog of this gene is CUX1.
Entrez Gene ID
23316
UniProt ID
O14529
Alternative Names
Cut Like Homeobox 2; Homeobox Protein Cux-2; CUTL2; Homeobox Protein Cut-Like 2; Cut-Like 2 (Drosophila); Cut-Like Homeobox 2; KIAA0293; CDP2;
Function
Transcription factor involved in the control of neuronal proliferation and differentiation in the brain. Regulates dendrite development and branching, dendritic spine formation, and synaptogenesis in cortical layers II-III. Binds to DNA in a sequence-specific manner.
Biological Process
Cellular response to organic substance Source: Ensembl
Cognition Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Positive regulation of dendrite morphogenesis Source: UniProtKB
Positive regulation of dendritic spine morphogenesis Source: UniProtKB
Positive regulation of excitatory postsynaptic potential Source: UniProtKB
Positive regulation of gene expression Source: UniProtKB
Positive regulation of synapse assembly Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Short-term memory Source: UniProtKB
Cellular Location
Nucleus
Involvement in disease
Developmental and epileptic encephalopathy 67 (DEE67):
A form of epileptic encephalopathy, a heterogeneous group of severe childhood onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. DEE67 is an autosomal dominant form characterized by onset of seizures in infancy. Later onset of seizures in childhood may occur in some patients.

Miškić, T., Kostović, I., Rašin, M. R., & Krsnik, Ž. (2021). Adult Upper Cortical Layer Specific Transcription Factor CUX2 Is Expressed in Transient Subplate and Marginal Zone Neurons of the Developing Human Brain. Cells, 10(2), 415.

Chen, I., Kuo, P. H., Yang, A. C., Tsai, S. J., Liu, T. H., Liu, H. J., ... & Liu, Y. L. (2020). CUX2, BRAP and ALDH2 are associated with metabolic traits in people with excessive alcohol consumption. Scientific reports, 10(1), 1-11.

Yang, H., Kim, J., Kim, Y., Jang, S. W., Sestan, N., & Shim, S. (2020). Cux2 expression regulated by Lhx2 in the upper layer neurons of the developing cortex. Biochemical and Biophysical Research Communications, 521(4), 874-879.

Pan, H., Yang, M., Lu, L., Tao, B., He, X., Chen, H., ... & Tang, S. (2019). Association of FAM65B, AGBL4, and CUX2 genetic polymorphisms with susceptibility to antituberculosis drug-induced hepatotoxicity: validation study in a Chinese Han population. Pharmacogenetics and genomics, 29(4), 84-90.

Sun, Y., Ye, D., Li, Y., Chen, E., Hao, R., Cai, Y., ... & Zhang, X. (2019). CUX2 functions as an oncogene in papillary thyroid cancer. OncoTargets and therapy, 12, 217.

Fregoso, S. P., Dwyer, B. E., & Franco, S. J. (2019). Lmx1a drives Cux2 expression in the cortical hem through activation of a conserved intronic enhancer. Development, 146(5), dev170068.

Chatron, N., Møller, R. S., Champaigne, N. L., Schneider, A. L., Kuechler, A., Labalme, A., ... & Lesca, G. (2018). The epilepsy phenotypic spectrum associated with a recurrent CUX2 variant. Annals of neurology, 83(5), 926-934.

Barington, M., Risom, L., Ek, J., Uldall, P., & Ostergaard, E. (2018). A recurrent de novo CUX2 missense variant associated with intellectual disability, seizures, and autism spectrum disorder. European Journal of Human Genetics, 26(9), 1388-1391.

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For research use only. Not intended for any clinical use.

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