CUX2

CUX2 (Cut Like Homeobox 2) is a Protein Coding gene. Diseases associated with CUX2 include Fiedler's Myocarditis. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding and RNA polymerase II regulatory region sequence-specific DNA binding. An important paralog of this gene is CUX1.

Full Name

cut-like homeobox 2

Function

Transcription factor involved in the control of neuronal proliferation and differentiation in the brain. Regulates dendrite development and branching, dendritic spine formation, and synaptogenesis in cortical layers II-III. Binds to DNA in a sequence-specific manner.

Biological Process

Cellular response to organic substance Source: Ensembl
Cognition Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Positive regulation of dendrite morphogenesis Source: UniProtKB
Positive regulation of dendritic spine morphogenesis Source: UniProtKB
Positive regulation of excitatory postsynaptic potential Source: UniProtKB
Positive regulation of gene expression Source: UniProtKB
Positive regulation of synapse assembly Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Short-term memory Source: UniProtKB

Cellular Location

Nucleus

Involvement in disease

Developmental and epileptic encephalopathy 67 (DEE67):
A form of epileptic encephalopathy, a heterogeneous group of severe childhood onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. DEE67 is an autosomal dominant form characterized by onset of seizures in infancy. Later onset of seizures in childhood may occur in some patients.