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Mouse Anti-CXCL13 Recombinant Antibody (53610) (CBMAB-C3320-LY)

This product is antibody recognizes CXCL13. The antibody 53610 immunoassay techniques such as: ELISA (Det), FC, Neutralization, WB.
See all CXCL13 antibodies
Published Data
Fig.1 IHC on representative spleen sections where CFSE-labeled adoptively transferred cells are green and B cells are labeled red.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
53610
Antibody Isotype
IgG1
Application
ELISA (Det), FC, Neutralization, WB

Basic Information

Immunogen
E. coli-derived recombinant human CXCL13/BLC/BCA-1 Val23-Arg94
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
C-X-C Motif Chemokine Ligand 13
Introduction
CXCL13 (C-X-C Motif Chemokine Ligand 13) is a Protein Coding gene. Diseases associated with CXCL13 include Angioimmunoblastic T-Cell Lymphoma and Burkitt Lymphoma. Among its related pathways are PEDF Induced Signaling and Akt Signaling. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and chemokine activity.
Entrez Gene ID
10563
UniProt ID
O43927
Alternative Names
C-X-C Motif Chemokine Ligand 13; Small Inducible Cytokine B Subfamily (Cys-X-Cys Motif), Member 13 (B-Cell Chemoattractant); B Cell-Attracting Chemokine 1; B Lymphocyte Chemoattractant; Small-Inducible Cytokine B13; B-Cell Chemoattractant; CXC Chemokine BLC; SCYB13; ANGIE; BCA-1; BCA1;
Function
Chemotactic for B-lymphocytes but not for T-lymphocytes, monocytes and neutrophils. Does not induce calcium release in B-lymphocytes. Binds to BLR1/CXCR5.
Biological Process
Activation of GTPase activity Source: BHF-UCL
Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
B cell chemotaxis Source: BHF-UCL
Cell-cell signaling Source: BHF-UCL
Cell surface receptor signaling pathway Source: BHF-UCL
Cellular response to lipopolysaccharide Source: GO_Central
Chemokine-mediated signaling pathway Source: GO_Central
Chronic inflammatory response Source: BHF-UCL
Defense response to bacterium Source: BHF-UCL
Endothelial cell chemotaxis to fibroblast growth factor Source: BHF-UCL
Germinal center formation Source: BHF-UCL
G protein-coupled receptor signaling pathway Source: Reactome
Immune response Source: BHF-UCL
Inflammatory response Source: GO_Central
Killing of cells of other organism Source: UniProtKB
Lymphocyte chemotaxis across high endothelial venule Source: BHF-UCL
Negative regulation of endothelial cell chemotaxis to fibroblast growth factor Source: BHF-UCL
Neutrophil chemotaxis Source: GO_Central
Positive regulation of cell-cell adhesion mediated by integrin Source: BHF-UCL
Positive regulation of cytosolic calcium ion concentration Source: BHF-UCL
Positive regulation of integrin activation Source: BHF-UCL
Positive regulation of T cell chemotaxis Source: BHF-UCL
Regulation of angiogenesis Source: BHF-UCL
Regulation of humoral immune response Source: BHF-UCL
Cellular Location
Secreted

Perreau, M., Suffiotti, M., Marques-Vidal, P., Wiedemann, A., Levy, Y., Laouénan, C., ... & Pantaleo, G. (2021). The cytokines HGF and CXCL13 predict the severity and the mortality in COVID-19 patients. Nature Communications, 12(1), 1-10.

Chen, F., Li, X., Li, Z., Zhou, Y., Qiang, Z., & Ma, H. (2020). The roles of chemokine (CXC motif) ligand 13 in spinal cord ischemia-reperfusion injury in rats. Brain Research, 1727, 146489.

Hussain, M., Adah, D., Tariq, M., Lu, Y., Zhang, J., & Liu, J. (2019). CXCL13/CXCR5 signaling axis in cancer. Life sciences, 227, 175-186.

Zhu, L., Zhang, G., Wang, P., Zhang, L., Ji, J., Liu, X., ... & Wang, X. (2019). The effect of CXC motif chemokine ligand 13 in cutaneous squamous cell carcinoma treated with aminolevulinic acid-photodynamic therapy. Photodiagnosis and Photodynamic Therapy, 26, 389-394.

Kazanietz, M. G., Durando, M., & Cooke, M. (2019). CXCL13 and its receptor CXCR5 in cancer: inflammation, immune response, and beyond. Frontiers in endocrinology, 10, 471.

Wei, Y., Lin, C., Li, H., Xu, Z., Wang, J., Li, R., ... & Xu, J. (2018). CXCL13 expression is prognostic and predictive for postoperative adjuvant chemotherapy benefit in patients with gastric cancer. Cancer Immunology, Immunotherapy, 67(2), 261-269.

Wagner, J. N., Weis, S., Kubasta, C., Panholzer, J., & von Oertzen, T. J. (2018). CXCL13 as a diagnostic marker of neuroborreliosis and other neuroinflammatory disorders in an unselected group of patients. Journal of Neurology, 265(1), 74-81.

Xu, L., Liang, Z., Li, S., & Ma, J. (2018). Signaling via the CXCR5/ERK pathway is mediated by CXCL13 in mice with breast cancer. Oncology Letters, 15(6), 9293-9298.

Meng, X., Yu, X., Dong, Q., Xu, X., Li, J., Xu, Q., ... & Zhou, C. (2018). Distribution of circulating follicular helper T cells and expression of interleukin‑21 and chemokine C‑X‑C ligand 13 in gastric cancer. Oncology Letters, 16(3), 3917-3922.

Pietikäinen, A., Oksi, J., & Hytönen, J. (2018). Point-of-care testing for CXCL13 in Lyme neuroborreliosis. Diagnostic Microbiology and Infectious Disease, 91(3), 226-228.

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For research use only. Not intended for any clinical use.

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