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Rabbit Anti-CXCL2 (AA 32-100) Recombinant Antibody (CBFYC-2516) (CBMAB-C2590-FY)

This product is rabbit antibody that recognizes CXCL2. The antibody CBFYC-2516 can be used for immunoassay techniques such as: IHC, WB.
See all CXCL2 antibodies

Summary

Host Animal
Rabbit
Specificity
Mouse, Rat
Clone
CBFYC-2516
Antibody Isotype
IgG
Application
IHC, WB

Basic Information

Immunogen
Recombinant protein corresponding to amino acids 32-100 of rat macrophage inflammatory protein 2
Specificity
Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
0.09% Sodium azide
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 32-100

Target

Full Name
chemokine (C-X-C motif) ligand 2
Introduction
CXCL2 (C-X-C Motif Chemokine Ligand 2) is a Protein Coding gene. Diseases associated with CXCL2 include Pneumonia and Peritonitis. Among its related pathways are PEDF Induced Signaling and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include chemokine activity and CXCR chemokine receptor binding. An important paralog of this gene is CXCL1.
Entrez Gene ID
Rat114105
Mouse20310
UniProt ID
RatP30348
MouseP10889
Alternative Names
GROb; Gro2; Mip2; Scyb; MIP-2; Scyb2; MIP-2a; Mgsa-b; CINC-2a
Function
Produced by activated monocytes and neutrophils and expressed at sites of inflammation. Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. GRO-beta(5-73) shows a highly enhanced hematopoietic activity.
Biological Process
Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Cellular response to lipopolysaccharide Source: GO_Central
Chemokine-mediated signaling pathway Source: GO_Central
Chemotaxis Source: ProtInc
Cytokine-mediated signaling pathway Source: Reactome
G protein-coupled receptor signaling pathway Source: Reactome
Inflammatory response Source: GO_Central
Killing of cells of other organism Source: UniProtKB
Neutrophil chemotaxis Source: GO_Central
Response to molecule of bacterial origin Source: BHF-UCL
Cellular Location
Secreted
PTM
The N-terminal processed form GRO-beta(5-73) is produced by proteolytic cleavage after secretion from bone marrow stromal cells.

Wang, X., Sun, L., He, N., An, Z., Yu, R., Li, C., ... & Zhao, J. (2021). Increased expression of CXCL2 in ACPA-positive rheumatoid arthritis and its role in osteoclastogenesis. Clinical & Experimental Immunology, 203(2), 194-208.

Guo, L. Y., Yang, F., Peng, L. J., Li, Y. B., & Wang, A. P. (2020). CXCL2, a new critical factor and therapeutic target for cardiovascular diseases. Clinical and Experimental Hypertension, 42(5), 428-437.

Hao, X., Gu, M., Sun, J., & Cong, L. (2020). A‐kinase interacting protein 1 might serve as a novel biomarker for worse prognosis through the interaction of chemokine (C‐X‐C motif) ligand 1/chemokine (C‐X‐C motif) ligand 2 in acute myeloid leukemia. Journal of Clinical Laboratory Analysis, 34(2), e23052.

Yang, J., Liu, H., Cao, Q., & Zhong, W. (2020). Characteristics of CXCL2 expression in coronary atherosclerosis and negative regulation by microRNA-421. Journal of International Medical Research, 48(2), 0300060519896150.

Yang, Y., Zhou, X., Li, Y., Chen, A., Liang, W., Liang, G., ... & Jin, D. (2019). CXCL2 attenuates osteoblast differentiation by inhibiting the ERK1/2 signaling pathway. Journal of Cell Science, 132(16), jcs230490.

Shi, H., Han, X., Sun, Y., Shang, C., Wei, M., Ba, X., & Zeng, X. (2018). Chemokine (C‐X‐C motif) ligand 1 and CXCL 2 produced by tumor promote the generation of monocytic myeloid‐derived suppressor cells. Cancer science, 109(12), 3826-3839.

Ding, J., Xu, K., Zhang, J., Lin, B., Wang, Y., Yin, S., ... & Zheng, S. (2018). Overexpression of CXCL2 inhibits cell proliferation and promotes apoptosis in hepatocellular carcinoma. BMB reports, 51(12), 630.

Noh, J. R., Kim, Y. H., Kim, D. K., Hwang, J. H., Kim, K. S., Choi, D. H., ... & Lee, C. H. (2018). Small heterodimer partner negatively regulates CXC motif chemokine ligand 2 in hepatocytes during liver inflammation. Scientific reports, 8(1), 1-11.

Lou, N., Richard, M. L. L., Yu, J., Kindy, M., & Zhang, X. K. (2017). The Fli-1 transcription factor is a critical regulator for controlling the expression of chemokine CXC motif ligand 2 (CXCL2). Molecular immunology, 81, 59-66.

Deftu, A. F., Filippi, A., Shibsaki, K., Gheorghe, R. O., Chiritoiu, M., & Ristoiu, V. (2017). Chemokine (CXC motif) ligand 1 (CXCL1) and chemokine (CXC motif) ligand 2 (CXCL2) modulate the activity of TRPV1+/IB4+ cultured rat dorsal root ganglia neurons upon short-term and acute application. Journal of Physiology and Pharmacology: an Official Journal of the Polish Physiological Society, 68(3), 385-395.

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For research use only. Not intended for any clinical use.

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