CXCL2
CXCL2 (C-X-C Motif Chemokine Ligand 2) is a Protein Coding gene. Diseases associated with CXCL2 include Pneumonia and Peritonitis. Among its related pathways are PEDF Induced Signaling and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include chemokine activity and CXCR chemokine receptor binding. An important paralog of this gene is CXCL1.
Full Name
chemokine (C-X-C motif) ligand 2
Function
Produced by activated monocytes and neutrophils and expressed at sites of inflammation. Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. GRO-beta(5-73) shows a highly enhanced hematopoietic activity.
Biological Process
Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Cellular response to lipopolysaccharide Source: GO_Central
Chemokine-mediated signaling pathway Source: GO_Central
Chemotaxis Source: ProtInc
Cytokine-mediated signaling pathway Source: Reactome
G protein-coupled receptor signaling pathway Source: Reactome
Inflammatory response Source: GO_Central
Killing of cells of other organism Source: UniProtKB
Neutrophil chemotaxis Source: GO_Central
Response to molecule of bacterial origin Source: BHF-UCL
Cellular response to lipopolysaccharide Source: GO_Central
Chemokine-mediated signaling pathway Source: GO_Central
Chemotaxis Source: ProtInc
Cytokine-mediated signaling pathway Source: Reactome
G protein-coupled receptor signaling pathway Source: Reactome
Inflammatory response Source: GO_Central
Killing of cells of other organism Source: UniProtKB
Neutrophil chemotaxis Source: GO_Central
Response to molecule of bacterial origin Source: BHF-UCL
Cellular Location
Secreted
PTM
The N-terminal processed form GRO-beta(5-73) is produced by proteolytic cleavage after secretion from bone marrow stromal cells.
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Anti-CXCL2 antibodies
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CompareTarget: Cxcl2
Sensitivity: 0.014 ng/mL
Detection Range: 0.03-9 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Rat
Assay Type: Sandwich
Reactivity: Rat
Target: CXCL2
Sensitivity: 0.0013 ng/mL
Detection Range: 0.002-0.6 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: Cxcl2
Sensitivity: 0.029 ng/mL
Detection Range: 0.05-20 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Rat
Assay Type: Sandwich
Reactivity: Rat
Target: CXCL2
Expressed Host: E. coli
Sequence: Amino Acid: 32-100
Target: CXCL2
Expressed Host: Yeast
Sequence: Amino Acid: 28-100
Tag: His Tag
Target: CXCL2
Expressed Host: E. coli
Sequence: Amino Acid: 28-100
Tag: His & SUMO Tag
Target: CXCL2
Expressed Host: E. coli
Sequence: Amino Acid: 35-107
Target: CXCL2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBXC-1496
Application*: E
Target: CXCL2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBFYC-2516
Application*: E
Target: CXCL2
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBFYC-2514
Application*: N, WB
Target: CXCL2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYC-2513
Application*: E
Target: CXCL2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYM-1061
Application*: E, WB
Target: CXCL2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Mouse, Rat
Clone: CBFYM-1060
Application*: E, WB
Target: CXCL2
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: G1497
Application*: E, WB
Target: CXCL2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Rat
Clone: G1496
Application*: E
Target: CXCL2
Host: Rat
Antibody Isotype: IgG2b
Specificity: Human, Mouse
Clone: CBYY-C0210
Application*: WB, N, E, IH
Target: CXCL2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Rat
Clone: CBFYC-2515
Application*: WB, N, E
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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