Rat Recombinant CXCL2 protein (V2LY-0526-LY9402)

Name: Rat Recombinant CXCL2 protein
SKU: V2LY-0526-LY9402
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

E. coli

Protein Species

Rat

Protein Construction

This product is Rat Recombinant CXCL2 protein consist of Amino Acid: 32-100 and predicts a molecular mass of 7.6 kDa.

Molecule Mass

7.6 kDa

Sequence

Amino Acid: 32-100

Species

Rat

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>85% as determined by SDS-PAGE.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

chemokine (C-X-C motif) ligand 2

Function

Produced by activated monocytes and neutrophils and expressed at sites of inflammation. Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. GRO-beta(5-73) shows a highly enhanced hematopoietic activity.

Biological Process

Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Cellular response to lipopolysaccharide Source: GO_Central
Chemokine-mediated signaling pathway Source: GO_Central
Chemotaxis Source: ProtInc
Cytokine-mediated signaling pathway Source: Reactome
G protein-coupled receptor signaling pathway Source: Reactome
Inflammatory response Source: GO_Central
Killing of cells of other organism Source: UniProtKB
Neutrophil chemotaxis Source: GO_Central
Response to molecule of bacterial origin Source: BHF-UCL

Cellular Location

Secreted

PTM

The N-terminal processed form GRO-beta(5-73) is produced by proteolytic cleavage after secretion from bone marrow stromal cells.

Wang, X., Sun, L., He, N., An, Z., Yu, R., Li, C., ... & Zhao, J. (2021). Increased expression of CXCL2 in ACPA-positive rheumatoid arthritis and its role in osteoclastogenesis. Clinical & Experimental Immunology, 203(2), 194-208.

Guo, L. Y., Yang, F., Peng, L. J., Li, Y. B., & Wang, A. P. (2020). CXCL2, a new critical factor and therapeutic target for cardiovascular diseases. Clinical and Experimental Hypertension, 42(5), 428-437.

Hao, X., Gu, M., Sun, J., & Cong, L. (2020). A‐kinase interacting protein 1 might serve as a novel biomarker for worse prognosis through the interaction of chemokine (C‐X‐C motif) ligand 1/chemokine (C‐X‐C motif) ligand 2 in acute myeloid leukemia. Journal of Clinical Laboratory Analysis, 34(2), e23052.

Yang, J., Liu, H., Cao, Q., & Zhong, W. (2020). Characteristics of CXCL2 expression in coronary atherosclerosis and negative regulation by microRNA-421. Journal of International Medical Research, 48(2), 0300060519896150.

Yang, Y., Zhou, X., Li, Y., Chen, A., Liang, W., Liang, G., ... & Jin, D. (2019). CXCL2 attenuates osteoblast differentiation by inhibiting the ERK1/2 signaling pathway. Journal of Cell Science, 132(16), jcs230490.

Shi, H., Han, X., Sun, Y., Shang, C., Wei, M., Ba, X., & Zeng, X. (2018). Chemokine (C‐X‐C motif) ligand 1 and CXCL 2 produced by tumor promote the generation of monocytic myeloid‐derived suppressor cells. Cancer science, 109(12), 3826-3839.

Ding, J., Xu, K., Zhang, J., Lin, B., Wang, Y., Yin, S., ... & Zheng, S. (2018). Overexpression of CXCL2 inhibits cell proliferation and promotes apoptosis in hepatocellular carcinoma. BMB reports, 51(12), 630.

Noh, J. R., Kim, Y. H., Kim, D. K., Hwang, J. H., Kim, K. S., Choi, D. H., ... & Lee, C. H. (2018). Small heterodimer partner negatively regulates CXC motif chemokine ligand 2 in hepatocytes during liver inflammation. Scientific reports, 8(1), 1-11.

Lou, N., Richard, M. L. L., Yu, J., Kindy, M., & Zhang, X. K. (2017). The Fli-1 transcription factor is a critical regulator for controlling the expression of chemokine CXC motif ligand 2 (CXCL2). Molecular immunology, 81, 59-66.

Deftu, A. F., Filippi, A., Shibsaki, K., Gheorghe, R. O., Chiritoiu, M., & Ristoiu, V. (2017). Chemokine (CXC motif) ligand 1 (CXCL1) and chemokine (CXC motif) ligand 2 (CXCL2) modulate the activity of TRPV1+/IB4+ cultured rat dorsal root ganglia neurons upon short-term and acute application. Journal of Physiology and Pharmacology: an Official Journal of the Polish Physiological Society, 68(3), 385-395.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant CXCL2 protein (CAT#: V2LY-0526-LY4423)

Mouse Recombinant CXCL2 protein, His & SUMO Tag (CAT#: V2LY-0526-LY8374)

Mouse Recombinant CXCL2 protein, His Tag (CAT#: V2LY-0526-LY8375)

Related Products

Human Recombinant CXCL2 protein (CAT#: V2LY-0526-LY4423)

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Mouse Anti-CXCL2 Recombinant Antibody (CBFYC-2515) (CAT#: CBMAB-C2589-FY)

Rabbit Anti-CXCL2 Recombinant Antibody (CBFYC-2516) (CAT#: V2LY-0125-LY699)

Rat Anti-CXCL2 Recombinant Antibody (G1497) (CAT#: V2LY-0125-LY693)

Mouse Recombinant CXCL2 protein, His Tag (CAT#: V2LY-0526-LY8375)

Mouse Anti-CXCL2 Recombinant Antibody (CBFYC-2513) (CAT#: V2LY-0125-LY696)

Rat Anti-CXCL2 Recombinant Antibody (CBYY-C0210) (CAT#: CBMAB-C0602-YY)

Mouse Recombinant CXCL2 protein, His & SUMO Tag (CAT#: V2LY-0526-LY8374)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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