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Mouse Anti-CXCR1 Recombinant Antibody (42705) (CBMAB-C1284-LY)

This product is antibody recognizes CXCR1. The antibody 42705 immunoassay techniques such as: FC, IHC, Neutralization, CyTOF.
See all CXCR1 antibodies
Published Data
Fig.1 Immunohistochemical expression of CXCR1 in FFPE tissues of GBM
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Fig.2 Immunocytochemistry (ICC) showing expression of IL-8, CXCR1, and CXCR2 in U-87MG and LN-18 cell lines.
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Fig.3 RT-PCR of IL-8, CXCR1, CXCR2, and GAPDH in U-87MG and LN-18 cell lines.
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Fig.4 Impact on the tubular structure in U-87MG cell line on neutralization with anti-CXCR1.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
42705
Antibody Isotype
IgG2a
Application
FC, IHC, Neutralization, CyTOF

Basic Information

Immunogen
NS0 mouse myeloma cell line transfected with human CXCR1/IL-8 RA, Met1-Leu350, Accession # AAA59159
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
C-X-C Motif Chemokine Receptor 1
Introduction
CXCR1 (C-X-C Motif Chemokine Receptor 1) is a Protein Coding gene. Diseases associated with CXCR1 include Human Immunodeficiency Virus Type 1 and Acute Pyelonephritis. Among its related pathways are Akt Signaling and Innate Immune System. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and interleukin-8 binding.
An important paralog of this gene is CXCR2.
Entrez Gene ID
3577
UniProt ID
P25024
Alternative Names
C-X-C Motif Chemokine Receptor 1; High Affinity Interleukin-8 Receptor A; Chemokine (C-X-C Motif) Receptor 1; Interleukin 8 Receptor, Alpha; IL-8 Receptor Type 1; IL-8R A; CDw128a; CMKAR1; CXC-R1; CXCR-1; IL8RA; C-X-C Chemokine Receptor Type 1;
Function
Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity.
Biological Process
Calcium-mediated signaling Source: GO_Central
Cell chemotaxis Source: GO_Central
Cell surface receptor signaling pathway Source: UniProtKB
Dendritic cell chemotaxis Source: BHF-UCL
G protein-coupled receptor signaling pathway Source: Reactome
Immune response Source: GO_Central
Neutrophil chemotaxis Source: GO_Central
Neutrophil degranulation Source: Reactome
Positive regulation of cytosolic calcium ion concentration Source: GO_Central
Receptor internalization Source: UniProtKB
Cellular Location
Cell membrane
Topology
Extracellular: 1-39
Helical: 40-66
Cytoplasmic: 67-75
Helical: 76-96
Extracellular: 97-111
Helical: 112-133
Cytoplasmic: 134-154
Helical: 155-174
Extracellular: 175-199
Helical: 200-220
Cytoplasmic: 221-242
Helical: 243-264
Extracellular: 265-285
Helical: 286-308
Cytoplasmic: 309-350
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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