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Mouse Anti-CXCR2 Recombinant Antibody (CBXC-2640) (CBMAB-C0932-CQ)

This product is a mouse antibody that recognizes CXCR2. The antibody CBXC-2640 can be used for immunoassay techniques such as: FC, IHC, IHC-P, IHC-Fr, Neut, CyTOF.
See all CXCR2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXC-2640
Antibody Isotype
IgG2
Application
FC, IHC, IHC-P, IHC-Fr, Neut, CyTOF

Basic Information

Immunogen
Human CXCR2
Specificity
Human
Antibody Isotype
IgG2
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
C-X-C Motif Chemokine Receptor 2
Introduction
CXCR2 (C-X-C Motif Chemokine Receptor 2) is a Protein Coding gene. Diseases associated with CXCR2 include Autosomal Recessive Severe Congenital Neutropenia Due To Cxcr2 Deficiency and Neutrophil Migration. Among its related pathways are Akt Signaling and Innate Immune System. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and C-X-C chemokine receptor activity. An important paralog of this gene is CXCR1.
Entrez Gene ID
3579
UniProt ID
P25025
Alternative Names
C-X-C Motif Chemokine Receptor 2; High Affinity Interleukin-8 Receptor B; Interleukin 8 Receptor, Beta; IL-8 Receptor Type 2; GRO/MGSA Receptor; IL-8R B; CDw128b; CXC-R2; CXCR-2; IL8RB; Chemokine (C-X-C Motif) Receptor 2;
Function
Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.
Biological Process
Calcium-mediated signaling Source: GO_Central
Cell chemotaxis Source: GO_Central
Cell surface receptor signaling pathway Source: UniProtKB
Cellular defense response Source: UniProtKB
Chemotaxis Source: UniProtKB
Dendritic cell chemotaxis Source: BHF-UCL
G protein-coupled receptor signaling pathway Source: Reactome
Immune response Source: GO_Central
Inflammatory response Source: ProtInc
Interleukin-8-mediated signaling pathway Source: UniProtKB
Neutrophil activation Source: UniProtKB
Neutrophil chemotaxis Source: UniProtKB
Neutrophil degranulation Source: Reactome
Phospholipase C-activating G protein-coupled receptor signaling pathway Source: UniProtKB
Positive regulation of cell population proliferation Source: UniProtKB
Positive regulation of cytosolic calcium ion concentration Source: GO_Central
Receptor internalization Source: UniProtKB
Signal transduction Source: ProtInc
Cellular Location
Cell membrane
Topology
Extracellular: 1-48
Helical: 49-75
Cytoplasmic: 76-84
Helical: 85-105
Extracellular: 106-120
Helical: 121-142
Cytoplasmic: 143-163
Helical: 164-183
Extracellular: 184-208
Helical: 209-231
Cytoplasmic: 232-251
Helical: 252-273
Extracellular: 274-294
Helical: 295-315
Cytoplasmic: 316-360
PTM
Phosphorylated upon ligand binding; which is required for desensitization.
(Microbial infection) Proteolytically cleaved by Staphylococcus aureus staphopain A/SspP. This cleavage inhibits CXCR2-dependent neutrophil activation and chemotaxis.

Liu, K., Shen, L., Wu, M., Liu, Z. J., & Hua, T. (2022). Structural insights into the activation of chemokine receptor CXCR2. The FEBS Journal, 289(2), 386-393.

Xu, M., Zheng, X., Wang, D., Fu, X., Xing, Y., Liu, Y., ... & Kong, X. (2021). Blockage of CXC Motif Chemokine Receptor 2 (CXCR2) Suppressed Uric Acid (UA)-Induced Cardiac Remodeling. Frontiers in Physiology, 12.

Zhao, B., Diao, J., Li, L., Kondo, H., Li, L., & Hirono, I. (2021). Molecular characterization and expression analysis of Japanese flounder (Paralichthys olivaceus) chemokine receptor CXCR2 in comparison with CXCR1. Developmental & Comparative Immunology, 120, 104047.

Liu, K., Wu, L., Yuan, S., Wu, M., Xu, Y., Sun, Q., ... & Liu, Z. J. (2020). Structural basis of CXC chemokine receptor 2 activation and signalling. Nature, 585(7823), 135-140.

Xue, D., Chen, W., & Neamati, N. (2020). Discovery, structure-activity relationship study and biological evaluation of 2-thioureidothiophene-3-carboxylates as a novel class of CXC chemokine receptor 2 (CXCR2) antagonists. European Journal of Medicinal Chemistry, 204, 112387.

Wei, L., Liu, Y., Ma, Y., Ding, C., Zhang, H., Lu, Z., ... & Zhu, C. (2019). CXC chemokine receptor 2 correlates with unfavorable prognosis and facilitates malignant cell activities via activating JAK2/STAT3 pathway in non-small cell lung cancer. Cell Cycle, 18(24), 3456-3471.

Wang, C. Y., Shang, M., Zhou, C. L., Feng, L. Z., Zhou, Q. S., & Hu, K. (2019). Mechanism of Cxc chemokine ligand 5 (CXCL5)/Cxc chemokine receptor 2 (CXCR2) bio-axis in mice with acute respiratory distress syndrome. Medical science monitor: international medical journal of experimental and clinical research, 25, 5299.

Busch-Petersen, J., Carpenter, D. C., Burman, M., Foley, J., Hunsberger, G. E., Kilian, D. J., ... & Tal-Singer, R. (2017). Danirixin: a reversible and selective antagonist of the CXC chemokine receptor 2. Journal of Pharmacology and Experimental Therapeutics, 362(2), 338-346.

Torraca, V., Otto, N. A., Tavakoli-Tameh, A., & Meijer, A. H. (2017). The inflammatory chemokine Cxcl18b exerts neutrophil-specific chemotaxis via the promiscuous chemokine receptor Cxcr2 in zebrafish. Developmental & Comparative Immunology, 67, 57-65.

Liang, D. Y., Shi, X., Liu, P., Sun, Y., Sahbaie, P., Li, W. W., ... & Clark, J. D. (2017). The chemokine receptor CXCR2 supports nociceptive sensitization after traumatic brain injury. Molecular Pain, 13, 1744806917730212.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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