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CXCR2

CXCR2 (C-X-C Motif Chemokine Receptor 2) is a Protein Coding gene. Diseases associated with CXCR2 include Autosomal Recessive Severe Congenital Neutropenia Due To Cxcr2 Deficiency and Neutrophil Migration. Among its related pathways are Akt Signaling and Innate Immune System. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and C-X-C chemokine receptor activity. An important paralog of this gene is CXCR1.

Full Name

C-X-C Motif Chemokine Receptor 2

Function

Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.

Biological Process

Calcium-mediated signaling Source: GO_Central
Cell chemotaxis Source: GO_Central
Cell surface receptor signaling pathway Source: UniProtKB
Cellular defense response Source: UniProtKB
Chemotaxis Source: UniProtKB
Dendritic cell chemotaxis Source: BHF-UCL
G protein-coupled receptor signaling pathway Source: Reactome
Immune response Source: GO_Central
Inflammatory response Source: ProtInc
Interleukin-8-mediated signaling pathway Source: UniProtKB
Neutrophil activation Source: UniProtKB
Neutrophil chemotaxis Source: UniProtKB
Neutrophil degranulation Source: Reactome
Phospholipase C-activating G protein-coupled receptor signaling pathway Source: UniProtKB
Positive regulation of cell population proliferation Source: UniProtKB
Positive regulation of cytosolic calcium ion concentration Source: GO_Central
Receptor internalization Source: UniProtKB
Signal transduction Source: ProtInc

Cellular Location

Cell membrane

Topology

Extracellular: 1-48
Helical: 49-75
Cytoplasmic: 76-84
Helical: 85-105
Extracellular: 106-120
Helical: 121-142
Cytoplasmic: 143-163
Helical: 164-183
Extracellular: 184-208
Helical: 209-231
Cytoplasmic: 232-251
Helical: 252-273
Extracellular: 274-294
Helical: 295-315
Cytoplasmic: 316-360

PTM

Phosphorylated upon ligand binding; which is required for desensitization.
(Microbial infection) Proteolytically cleaved by Staphylococcus aureus staphopain A/SspP. This cleavage inhibits CXCR2-dependent neutrophil activation and chemotaxis.

Anti-CXCR2 antibodies

Mouse Anti-CXCR2 Recombinant Antibody (CBWJC-3494) (CBMAB-C4724WJ)

SDS

Target: CXCR2

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBWJC-3494

Application*: WB

Mouse Anti-CXCR2 Recombinant Antibody (HC 2) (CBMAB-C2788WJ)

SDS

Target: CXCR2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: HC 2

Application*: F, IH, WB

Mouse Anti-CXCR2 Recombinant Antibody (CBWJC-2096) (CBMAB-C2787WJ)

SDS

Target: CXCR2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBWJC-2096

Application*: F

Mouse Anti-CXCR2 Recombinant Antibody (CBXC-0630) (CBMAB-C4724-CQ)

SDS

Target: CXCR2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXC-0630

Application*: IH, F

Mouse Anti-CXCR2 Recombinant Antibody (CBXC-2590) (CBMAB-C4722-CQ)

SDS

Target: CXCR2

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBXC-2590

Application*: WB

Mouse Anti-CXCR2 Recombinant Antibody (CBXC-0631) (CBMAB-C4721-CQ)

SDS

Target: CXCR2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXC-0631

Application*: F, P

Human Anti-CXCR2 Recombinant Antibody (CBXC-0745) (CBMAB-C1859-CQ)

SDS

Target: CXCR2

Host: Human

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXC-0745

Application*: F

Mouse Anti-CXCR2 Recombinant Antibody (CBXC-1211) (CBMAB-C1478-CQ)

SDS

Target: CXCR2

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBXC-1211

Application*: F

Mouse Anti-CXCR2 Recombinant Antibody (CBXC-2640) (CBMAB-C0932-CQ)

SDS

Target: CXCR2

Host: Mouse

Antibody Isotype: IgG2

Specificity: Human

Clone: CBXC-2640

Application*: F, IH, P, C, N, MC

Mouse Anti-CXCR2 Recombinant Antibody (CBYY-C2365) (CBMAB-C3803-YY)

SDS

Target: CXCR2

Host: Mouse

Antibody Isotype: IgG2

Specificity: Human

Clone: CBYY-C2365

Application*: F, C, N

Mouse Anti-CXCR2 Recombinant Antibody (CBYY-C2364) (CBMAB-C3802-YY)

SDS

Target: CXCR2

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBYY-C2364

Application*: E

Rat Anti-CXCR2 Recombinant Antibody (242216) (CBMAB-C0714-LY)

SDS

Target: CXCR2

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: 242216

Application*: F, N, MC

Mouse Anti-CXCR2 Recombinant Antibody (866614) (CBMAB-C8991-LY)

SDS

Target: CXCR2

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Rat

Clone: 866614

Application*: F, MC

Rat Anti-CXCR2 Recombinant Antibody (CBFYC-0467) (CBMAB-C0513-FY)

SDS

Target: CXCR2

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: CBFYC-0467

Application*: F

Rat Anti-CXCR2 Recombinant Antibody (CBFYC-2533) (CBMAB-C2607-FY)

SDS

Target: CXCR2

Host: Rat

Antibody Isotype: IgG2

Specificity: Mouse

Clone: CBFYC-2533

Application*: F, N

Mouse Anti-CXCR2 (AA 1-19) Recombinant Antibody (CBFYC-2534) (CBMAB-C2608-FY)

SDS

Target: CXCR2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYC-2534

Application*: E, F, FN, IF, C, P, WB

Mouse Anti-CXCR2 Recombinant Antibody (CBFYC-2536) (CBMAB-C2610-FY)

SDS

Target: CXCR2

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBFYC-2536

Application*: F

Mouse Anti-CXCR2 Recombinant Antibody (CBYY-C0367) (CBMAB-C1266-YY)

SDS

Target: CXCR2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBYY-C0367

Application*: F

Mouse Anti-CXCR2 Recombinant Antibody (CBYY-C0535) (CBMAB-C1607-YY)

SDS

Target: CXCR2

Host: Mouse

Antibody Isotype: IgG1, λ

Specificity: Human

Clone: CBYY-C0535

Application*: F

Mouse Anti-CXCR2 Recombinant Antibody (48311) (CBMAB-C1343-LY)

SDS

Target: CXCR2

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 48311

Application*: F, IH, N, MC

Mouse Anti-CXCR2 Recombinant Antibody (13A201) (CBMAB-C2741-LY)

SDS

Target: CXCR2

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 13A201

Application*: F

Mouse Anti-CXCR2 Recombinant Antibody (19) (CBMAB-C3469-LY)

SDS

Target: CXCR2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 19

Application*: WB, E, P, F, B, IC/IF

Mouse Anti-CXCR2 Recombinant Antibody (3M9) (CBMAB-C6400-LY)

SDS

Target: CXCR2

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 3M9

Application*: E

Mouse Anti-CXCR2 Recombinant Antibody (48311.211) (CBMAB-C6521-LY)

SDS

Target: CXCR2

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 48311.211

Application*: F, I

Mouse Anti-CXCR2 Recombinant Antibody (5E8-C7-F10) (CBMAB-C7523-LY)

SDS

Target: CXCR2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 5E8-C7-F10

Application*: F

Mouse Anti-CXCR2 Recombinant Antibody (6D499) (CBMAB-C8214-LY)

SDS

Target: CXCR2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 6D499

Application*: P, F

Mouse Anti-CXCR2 Recombinant Antibody (7J40) (CBMAB-C8875-LY)

SDS

Target: CXCR2

Host: Mouse

Antibody Isotype: IgG2

Specificity: Human

Clone: 7J40

Application*: F, C, N

Mouse Anti-CXCR2 Recombinant Antibody (14L326) (CBMAB-C3239-CN)

SDS

Target: CXCR2

Host: Mouse

Antibody Isotype: IgG2

Specificity: Human

Clone: 14L326

Application*: FC, IH, N

Mouse Anti-CXCR2 Recombinant Antibody (6D498) (CBMAB-C3240-CN)

SDS

Target: CXCR2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 6D498

Application*: FC, IH, WB

Mouse Anti-CXCR2 Recombinant Antibody (CBCNC-535) (CBMAB-C3243-CN)

SDS

Target: CXCR2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBCNC-535

Application*: E, FC, IH, N, WB

Mouse Anti-CXCR2 Recombinant Antibody (CBCNC-536) (CBMAB-C3244-CN)

SDS

Target: CXCR2

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBCNC-536

Application*: FC

Mouse Anti-CXCR2 Recombinant Antibody (CBCNC-537) (CBMAB-C3245-CN)

SDS

Target: CXCR2

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBCNC-537

Application*: FC

Rat Anti-CXCR2 Recombinant Antibody (SA044G4) (CBMAB-C11399-LY)

SDS

Target: CXCR2

Host: Rat

Antibody Isotype: IgG2a, κ

Specificity: Mouse

Clone: SA044G4

Application*: F

Rat Anti-CXCR2 Recombinant Antibody (RM0212-24D12) (CBMAB-C11398-LY)

SDS

Target: CXCR2

Host: Rat

Antibody Isotype: IgG2

Specificity: Mouse

Clone: RM0212-24D12

Application*: F

Mouse Anti-CXCR2 Recombinant Antibody (MM0222-7J40) (CBMAB-C11401-LY)

SDS

Target: CXCR2

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: MM0222-7J40

Application*: C, N, F

Mouse Anti-CXCR2 Recombinant Antibody (RII115) (CBMAB-C11402-LY)

SDS

Target: CXCR2

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: RII115

Application*: F

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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