Mouse Anti-CXCR2 Recombinant Antibody (CBXC-2590) (V2LY-0125-LY778)

Name: Mouse Anti-CXCR2 Recombinant Antibody (CBXC-2590)
SKU: V2LY-0125-LY778
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXC-2590

Application

Immunogen

Recombinant Human IL8Rb protein, Met1-Leu57.

Host Species

Mouse

Specificity

Human, Pig

Antibody Isotype

IgG1, κ

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	0.5-2 μg/mL

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

Glycerol & PBS

Preservative

Sodium Azide

Concentration

1 mg/mL

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

C-X-C Motif Chemokine Receptor 2

Entrez Gene ID

3579

UniProt ID

P25025

Function

Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.

Biological Process

Calcium-mediated signaling Source: GO_Central
Cell chemotaxis Source: GO_Central
Cell surface receptor signaling pathway Source: UniProtKB
Cellular defense response Source: UniProtKB
Chemotaxis Source: UniProtKB
Dendritic cell chemotaxis Source: BHF-UCL
G protein-coupled receptor signaling pathway Source: Reactome
Immune response Source: GO_Central
Inflammatory response Source: ProtInc
Interleukin-8-mediated signaling pathway Source: UniProtKB
Neutrophil activation Source: UniProtKB
Neutrophil chemotaxis Source: UniProtKB
Neutrophil degranulation Source: Reactome
Phospholipase C-activating G protein-coupled receptor signaling pathway Source: UniProtKB
Positive regulation of cell population proliferation Source: UniProtKB
Positive regulation of cytosolic calcium ion concentration Source: GO_Central
Receptor internalization Source: UniProtKB
Signal transduction Source: ProtInc

Cellular Location

Cell membrane

Topology

Extracellular: 1-48
Helical: 49-75
Cytoplasmic: 76-84
Helical: 85-105
Extracellular: 106-120
Helical: 121-142
Cytoplasmic: 143-163
Helical: 164-183
Extracellular: 184-208
Helical: 209-231
Cytoplasmic: 232-251
Helical: 252-273
Extracellular: 274-294
Helical: 295-315
Cytoplasmic: 316-360

PTM

Phosphorylated upon ligand binding; which is required for desensitization.
(Microbial infection) Proteolytically cleaved by Staphylococcus aureus staphopain A/SspP. This cleavage inhibits CXCR2-dependent neutrophil activation and chemotaxis.

Liu, K., Shen, L., Wu, M., Liu, Z. J., & Hua, T. (2022). Structural insights into the activation of chemokine receptor CXCR2. The FEBS Journal, 289(2), 386-393.

Xu, M., Zheng, X., Wang, D., Fu, X., Xing, Y., Liu, Y., ... & Kong, X. (2021). Blockage of CXC Motif Chemokine Receptor 2 (CXCR2) Suppressed Uric Acid (UA)-Induced Cardiac Remodeling. Frontiers in Physiology, 12.

Zhao, B., Diao, J., Li, L., Kondo, H., Li, L., & Hirono, I. (2021). Molecular characterization and expression analysis of Japanese flounder (Paralichthys olivaceus) chemokine receptor CXCR2 in comparison with CXCR1. Developmental & Comparative Immunology, 120, 104047.

Liu, K., Wu, L., Yuan, S., Wu, M., Xu, Y., Sun, Q., ... & Liu, Z. J. (2020). Structural basis of CXC chemokine receptor 2 activation and signalling. Nature, 585(7823), 135-140.

Xue, D., Chen, W., & Neamati, N. (2020). Discovery, structure-activity relationship study and biological evaluation of 2-thioureidothiophene-3-carboxylates as a novel class of CXC chemokine receptor 2 (CXCR2) antagonists. European Journal of Medicinal Chemistry, 204, 112387.

Wei, L., Liu, Y., Ma, Y., Ding, C., Zhang, H., Lu, Z., ... & Zhu, C. (2019). CXC chemokine receptor 2 correlates with unfavorable prognosis and facilitates malignant cell activities via activating JAK2/STAT3 pathway in non-small cell lung cancer. Cell Cycle, 18(24), 3456-3471.

Wang, C. Y., Shang, M., Zhou, C. L., Feng, L. Z., Zhou, Q. S., & Hu, K. (2019). Mechanism of Cxc chemokine ligand 5 (CXCL5)/Cxc chemokine receptor 2 (CXCR2) bio-axis in mice with acute respiratory distress syndrome. Medical science monitor: international medical journal of experimental and clinical research, 25, 5299.

Busch-Petersen, J., Carpenter, D. C., Burman, M., Foley, J., Hunsberger, G. E., Kilian, D. J., ... & Tal-Singer, R. (2017). Danirixin: a reversible and selective antagonist of the CXC chemokine receptor 2. Journal of Pharmacology and Experimental Therapeutics, 362(2), 338-346.

Torraca, V., Otto, N. A., Tavakoli-Tameh, A., & Meijer, A. H. (2017). The inflammatory chemokine Cxcl18b exerts neutrophil-specific chemotaxis via the promiscuous chemokine receptor Cxcr2 in zebrafish. Developmental & Comparative Immunology, 67, 57-65.

Liang, D. Y., Shi, X., Liu, P., Sun, Y., Sahbaie, P., Li, W. W., ... & Clark, J. D. (2017). The chemokine receptor CXCR2 supports nociceptive sensitization after traumatic brain injury. Molecular Pain, 13, 1744806917730212.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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For research use only. Not intended for any clinical use.

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