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Mouse Anti-CXCR5 Recombinant Antibody (CBYY-C2373) (CBMAB-C3811-YY)

This product is mouse antibody that recognizes CXCR5. The antibody CBYY-C2373 can be used for immunoassay techniques such as: FC, IHC, Neut
See all CXCR5 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-C2373
Antibody Isotype
IgG2
Application
FC, IHC, Neut

Basic Information

Immunogen
Human recombinant CXCR5
Specificity
Human
Antibody Isotype
IgG2
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Protein G purified
Preservative
PBS
Concentration
Lyophilized
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
C-X-C Motif Chemokine Receptor 5
Entrez Gene ID
643
UniProt ID
P32302
Alternative Names
Cysteine Rich Tail 1; C9orf169; Similar To RIKEN CDNA 2310002J15 Gene; Chromosome 9 Open Reading Frame 169; Cysteine-Rich Tail Protein 1; UPF0574 Protein C9orf169;
Function
Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral lymph nodes. May have a regulatory function in Burkitt lymphoma (BL) lymphomagenesis and/or B-cell differentiation.
Biological Process
B cell activation Source: UniProtKB-KW
Calcium-mediated signaling Source: GO_Central
Cell chemotaxis Source: GO_Central
G protein-coupled receptor signaling pathway Source: Reactome
Immune response Source: GO_Central
Leukocyte chemotaxis Source: Ensembl
Lymph node development Source: Ensembl
Positive regulation of cytokinesis Source: UniProtKB
Positive regulation of cytosolic calcium ion concentration Source: GO_Central
Cellular Location
Cell membrane
Topology
Extracellular: 1-55
Helical: 56-76
Cytoplasmic: 77-88
Helical: 89-109
Extracellular: 110-124
Helical: 125-145
Cytoplasmic: 146-167
Helical: 168-188
Extracellular: 189-219
Helical: 220-240
Cytoplasmic: 241-259
Helical: 260-280
Extracellular: 281-304
Helical: 305-325
Cytoplasmic: 326-372

Saddala, M. S., Lennikov, A., Mukwaya, A., Yang, X., Tang, S., & Huang, H. (2021). Data mining and network analysis reveals CXC chemokine receptor type 5 is involved in the pathophysiology of age-related macular degeneration. Journal of Biomolecular Structure and Dynamics, 1-10.

Saddala, M. S., Lennikov, A., & Huang, H. (2020). RNA-seq data from CXC chemokine receptor type 5 (CXCR5) gene knockout aged mice with retinal degeneration phenotype. Data in brief, 31, 105915.

Li, W., Yang, D., Zhang, Y., Zhao, S., Li, D., & Liu, M. (2020). Long non‑coding RNA PLK1S1 was associated with renal cell carcinoma progression by interacting with microRNA‑653 and altering C‑X‑C chemokine receptor 5 expression. Oncology Reports, 44(5), 1985-1996.

Ekman, I., Ihantola, E. L., Viisanen, T., Rao, D. A., Näntö-Salonen, K., Knip, M., ... & Kinnunen, T. (2019). Circulating CXCR5− PD-1hi peripheral T helper cells are associated with progression to type 1 diabetes. Diabetologia, 62(9), 1681-1688.

Hussain, M., Adah, D., Tariq, M., Lu, Y., Zhang, J., & Liu, J. (2019). CXCL13/CXCR5 signaling axis in cancer. Life sciences, 227, 175-186.

Xu, L., Liang, Z., Li, S., & Ma, J. (2018). Signaling via the CXCR5/ERK pathway is mediated by CXCL13 in mice with breast cancer. Oncology Letters, 15(6), 9293-9298.

Aqrawi, L. A., Ivanchenko, M., Björk, A., Ramírez Sepúlveda, J. I., Imgenberg-Kreuz, J., Kvarnström, M., ... & Wahren-Herlenius, M. (2018). Diminished CXCR5 expression in peripheral blood of patients with Sjögren's syndrome may relate to both genotype and salivary gland homing. Clinical & Experimental Immunology, 192(3), 259-270.

Li, R., Ma, L., Huang, H., Ou, S., Yuan, J., Xu, T., ... & Peng, X. (2017). Altered expression of CXCL13 and CXCR5 in intractable temporal lobe epilepsy patients and pilocarpine-induced epileptic rats. Neurochemical research, 42(2), 526-540.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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