Mouse Anti-CXXC1 Recombinant Antibody (35) (CBMAB-C5557-LY)

This product is antibody recognizes CGBP. The antibody 35 immunoassay techniques such as: WB, IP, IF.
See all CXXC1 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Mouse, Rat, Human

Clone

Antibody Isotype

IgG

Application

WB, IP, IF

Basic Information

Specificity

Mouse, Rat, Human

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

CXXC1

Entrez Gene ID

Human	30827
Mouse	74322
Rat	291440

UniProt ID

Human	Q9P0U4
Mouse	Q9CWW7
Rat	A1A5S2

Function

Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG.

Biological Process

Histone H3-K4 methylation Source: UniProtKB
IRE1-mediated unfolded protein response Source: Reactome
Positive regulation of transcription, DNA-templated Source: UniProtKB
Regulation of transcription, DNA-templated Source: UniProtKB

Cellular Location

Nucleus speckle; Nucleus. Associated with euchromatin. During mitosis, excluded from condensed chromosomes.

PTM

May be regulated by proteolysis.

References

Sha, Q. Q., Zhu, Y. Z., Xiang, Y., Yu, J. L., Fan, X. Y., Li, Y. C., ... & Fan, H. Y. (2021). Role of CxxC-finger protein 1 in establishing mouse oocyte epigenetic landscapes. Nucleic acids research, 49(5), 2569-2582.

Jiang, Y., Zhang, H. Y., Lin, Z., Zhu, Y. Z., Yu, C., Sha, Q. Q., ... & Fan, H. Y. (2020). CXXC finger protein 1-mediated histone H3 lysine-4 trimethylation is essential for proper meiotic crossover formation in mice. Development, 147(6), dev183764.

Lin, F., Meng, X., Guo, Y., Cao, W., Liu, W., Xia, Q., ... & Wang, L. (2019). Epigenetic initiation of the TH17 differentiation program is promoted by Cxxc finger protein 1. Science advances, 5(10), eaax1608.

Karra, A. S., Klein, A. M., Earnest, S., Stippec, S., Wichaidit, C., McGlynn, K., ... & Cobb, M. H. (2019). ERK2 phosphorylates the epigenetic regulator CXXC-finger protein 1 (CFP1). bioRxiv, 562173.

Hui, Z., Zhou, L., Xue, Z., Zhou, L., Luo, Y., Lin, F., ... & Wang, L. (2018). Cxxc finger protein 1 positively regulates GM-CSF-derived macrophage phagocytosis through Csf2rα-mediated signaling. Frontiers in immunology, 1885.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Alternative Versions

Mouse Anti-CXXC1 Recombinant Antibody (35)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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