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Rabbit Anti-CYP26C1 Recombinant Antibody (EG889) (CBMAB-EN1060-LY)

The product is antibody recognizes CYP26C1. The antibody EG889 immunoassay techniques such as: IHC: 1:50~1:100 ELISA: 1:40000.
See all CYP26C1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
EG889
Antibody Isotype
IgG
Application
IHC: 1:50~1:100 ELISA: 1:40000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human Cytochrome P450 26C1.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Cytochrome P450 Family 26 Subfamily C Member 1
Introduction
CYP26C1 (Cytochrome P450 Family 26 Subfamily C Member 1) is a Protein Coding gene. Diseases associated with CYP26C1 include Focal Facial Dermal Dysplasia 4 and Focal Facial Dermal Dysplasia. Among its related pathways are Metabolism and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP26B1.
Entrez Gene ID
340665
UniProt ID
Q6V0L0
Alternative Names
Cytochrome P450 Family 26 Subfamily C Member 1; Cytochrome P450, Family 26, Subfamily C, Polypeptide 1; Cytochrome P450 26C1; EC 1.14.-.-; FFDD4;
Function
Plays a role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA (preferred substrate).
Biological Process
Anterior/posterior pattern specification Source: BHF-UCL
Central nervous system development Source: BHF-UCL
Negative regulation of retinoic acid receptor signaling pathway Source: BHF-UCL
Neural crest cell development Source: BHF-UCL
Organelle fusion Source: BHF-UCL
Retinoic acid catabolic process Source: BHF-UCL
Sterol metabolic process Source: GO_Central
Vitamin metabolic process Source: Reactome
Cellular Location
Membrane
Involvement in disease
Focal facial dermal dysplasia 4 (FFDD4):
A form of focal facial dermal dysplasia, a group of developmental defects characterized by bitemporal or preauricular skin lesions resembling aplasia cutis congenita. Skin defects occur at the sites of facial fusion during embryogenesis, with temporal lesions situated at the junction between the frontonasal and maxillary facial prominences, and preauricular lesions at the meeting point of the maxillary and mandibular prominences. The ectodermal lesions show consistent histologic abnormalities: atrophy and flattening of the epidermis, replacement of the dermis by loose connective tissue, reduced levels of fragmented elastic tissue and absence of the subcutaneous tissues and adnexal structures. FFDD4 is characterized by isolated, preauricular skin lesions.
Topology
Helical: 9-29
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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