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Mouse Anti-CYP2A6 Recombinant Antibody (1D2) (CBMAB-C3819-LY)

This product is antibody recognizes CYP2A6. The antibody 1D2 immunoassay techniques such as: WB, FC, IHC, IHC-P.
See all CYP2A6 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
1D2
Antibody Isotype
IgG2b
Application
WB, FC, IHC, IHC-P

Basic Information

Immunogen
Full length human recombinant protein of human CYP2A6(NP_000753) produced in HEK293T cell
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Cytochrome P450 Family 2 Subfamily A Member 6
Introduction
CYP2A6 (Cytochrome P450 Family 2 Subfamily A Member 6) is a Protein Coding gene. Diseases associated with CYP2A6 include Tobacco Addiction and Coumarin Resistance. Among its related pathways are superpathway of steroid hormone biosynthesis and superpathway of tryptophan utilization. Gene Ontology (GO) annotations related to this gene include enzyme binding and heme binding.
An important paralog of this gene is CYP2A7.
Entrez Gene ID
1548
UniProt ID
P11509
Alternative Names
Cytochrome P450 Family 2 Subfamily A Member 6; Cytochrome P450, Subfamily IIA (Phenobarbital-Inducible), Polypeptide 6; Cytochrome P450, Family 2, Subfamily A, Polypeptide 6; 1,4-Cineole 2-Exo-Monooxygenase; Coumarin 7-Hydroxylase; Cytochrome P450 IIA3; Cytochrome P450(I); CYPIIA6; CYP2A3; Flavoprotein-Linked Monooxygenase;
Function
Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. Acts as a 1,4-cineole 2-exo-monooxygenase. Possesses low phenacetin O-deethylation activity.
Biological Process
Coumarin catabolic process Source: BHF-UCL
Coumarin metabolic process Source: BHF-UCL
Drug metabolic process Source: BHF-UCL
Epoxygenase P450 pathway Source: GO_Central
Exogenous drug catabolic process Source: BHF-UCL
Organic acid metabolic process Source: GO_Central
Steroid metabolic process Source: BHF-UCL
Xenobiotic metabolic process Source: GO_Central
Cellular Location
Endoplasmic reticulum membrane; Microsome membrane

Yoon, H. Y., Ahn, M. H., Yee, J., Lee, N., Han, J. M., & Gwak, H. S. (2020). Influence of CYP2C9 and CYP2A6 on plasma concentrations of valproic acid: a meta-analysis. European journal of clinical pharmacology, 76(8), 1053-1058.

El‐Boraie, A., Taghavi, T., Chenoweth, M. J., Fukunaga, K., Mushiroda, T., Kubo, M., ... & Tyndale, R. F. (2020). Evaluation of a weighted genetic risk score for the prediction of biomarkers of CYP2A6 activity. Addiction biology, 25(1), e12741.

Tanner, J. A., Zhu, A. Z., Claw, K. G., Prasad, B., Korchina, V., Hu, J., ... & Tyndale, R. F. (2018). Novel CYP2A6 diplotypes identified through next-generation sequencing are associated with in vitro and in vivo nicotine metabolism. Pharmacogenetics and genomics, 28(1), 7.

Ren, X., Ji, Y., Jiang, X., & Qi, X. (2018). Downregulation of CYP2A6 and CYP2C8 in tumor tissues is linked to worse overall survival and recurrence-free survival from hepatocellular carcinoma. BioMed research international, 2018.

Yuan, J. M., Nelson, H. H., Carmella, S. G., Wang, R., Kuriger-Laber, J., Jin, A., ... & Murphy, S. E. (2017). CYP2A6 genetic polymorphisms and biomarkers of tobacco smoke constituents in relation to risk of lung cancer in the Singapore Chinese Health Study. Carcinogenesis, 38(4), 411-418.

Park, S. L., Murphy, S. E., Wilkens, L. R., Stram, D. O., Hecht, S. S., & Le Marchand, L. (2017). Association of CYP2A6 activity with lung cancer incidence in smokers: The multiethnic cohort study. PLoS One, 12(5), e0178435.

Tanner, J. A., Prasad, B., Claw, K. G., Stapleton, P., Chaudhry, A., Schuetz, E. G., ... & Tyndale, R. F. (2017). Predictors of variation in CYP2A6 mRNA, protein, and enzyme activity in a human liver bank: influence of genetic and nongenetic factors. Journal of Pharmacology and Experimental Therapeutics, 360(1), 129-139.

López-Flores, L. A., Pérez-Rubio, G., & Falfán-Valencia, R. (2017). Distribution of polymorphic variants of CYP2A6 and their involvement in nicotine addiction. EXCLI journal, 16, 174.

Tanner, J. A., & Tyndale, R. F. (2017). Variation in CYP2A6 activity and personalized medicine. Journal of personalized medicine, 7(4), 18.

Pérez-Rubio, G., López-Flores, L. A., Ramírez-Venegas, A., Noé-Díaz, V., García-Gómez, L., Ambrocio-Ortiz, E., ... & Falfán-Valencia, R. (2017). Genetic polymorphisms in CYP2A6 are associated with a risk of cigarette smoking and predispose to smoking at younger ages. Gene, 628, 205-210.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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