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CYP2A6

CYP2A6 (Cytochrome P450 Family 2 Subfamily A Member 6) is a Protein Coding gene. Diseases associated with CYP2A6 include Tobacco Addiction and Coumarin Resistance. Among its related pathways are superpathway of steroid hormone biosynthesis and superpathway of tryptophan utilization. Gene Ontology (GO) annotations related to this gene include enzyme binding and heme binding. An important paralog of this gene is CYP2A7.

Full Name

Cytochrome P450 Family 2 Subfamily A Member 6

Function

Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. Acts as a 1,4-cineole 2-exo-monooxygenase. Possesses low phenacetin O-deethylation activity.

Biological Process

Coumarin catabolic process Source: BHF-UCL
Coumarin metabolic process Source: BHF-UCL
Drug metabolic process Source: BHF-UCL
Epoxygenase P450 pathway Source: GO_Central
Exogenous drug catabolic process Source: BHF-UCL
Organic acid metabolic process Source: GO_Central
Steroid metabolic process Source: BHF-UCL
Xenobiotic metabolic process Source: GO_Central

Cellular Location

Endoplasmic reticulum membrane; Microsome membrane

Anti-CYP2A6 antibodies

Rabbit Anti-CYP2A6 Recombinant Antibody (EG892) (CBMAB-EN1063-LY)

SDS

Target: CYP2A6

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: EG892

Application*: WB: 1:500~1:1000 ELISA: 1:20000

Mouse Anti-CYP2A6 Recombinant Antibody (1D2) (CBMAB-C3819-LY)

SDS

Target: CYP2A6

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human, Mouse, Rat

Clone: 1D2

Application*: WB, F, IH, P

Mouse Anti-CYP2A6 Recombinant Antibody (2A8) (CBMAB-C4636-LY)

SDS

Target: CYP2A6

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 2A8

Application*: F, C, WB

Mouse Anti-CYP2A6 Recombinant Antibody (3B11) (CBMAB-C5688-LY)

SDS

Target: CYP2A6

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 3B11

Application*: E, WB

Mouse Anti-CYP2A6 Recombinant Antibody (3C1) (CBMAB-C5772-LY)

SDS

Target: CYP2A6

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 3C1

Application*: F, IF, P, WB

Mouse Anti-CYP2A6 Recombinant Antibody (CBYY-C2395) (CBMAB-C3833-YY)

SDS

Target: CYP2A6

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBYY-C2395

Application*: F, IF, P, WB

Mouse Anti-CYP2A6 Recombinant Antibody (CBCNC-560) (CBMAB-C3305-CN)

SDS

Target: CYP2A6

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBCNC-560

Application*: E, IH, WB

Mouse Anti-CYP2A6 Recombinant Antibody (CBFYC-2572) (CBMAB-C2646-FY)

SDS

Target: CYP2A6

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBFYC-2572

Application*: F, IH, WB

Mouse Anti-CYP2A6 Recombinant Antibody (F16 P2 D8) (CBMAB-C0657-CQ)

SDS

Target: CYP2A6

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: F16 P2 D8

Application*: WB, E, IH

Mouse Anti-CYP2A6 Recombinant Antibody (RP1.2B4) (CBMAB-C1025-CQ)

SDS

Target: CYP2A6

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: RP1.2B4

Application*: WB

Mouse Anti-CYP2A6 Recombinant Antibody (CBXC-2949) (CBMAB-C4310-CQ)

SDS

Target: CYP2A6

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBXC-2949

Application*: WB, IH, IF, F

Mouse Anti-CYP2A6 Recombinant Antibody (CBXC-3129) (CBMAB-C4312-CQ)

SDS

Target: CYP2A6

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBXC-3129

Application*: WB, IH

Mouse Anti-CYP2A6 Recombinant Antibody (CBWJC-3546) (CBMAB-C4779WJ)

SDS

Target: CYP2A6

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBWJC-3546

Application*: P, WB

Mouse Anti-CYP2A6 Recombinant Antibody (CBWJC-3547) (CBMAB-C4780WJ)

SDS

Target: CYP2A6

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human, Rat, Monkey, Mouse

Clone: CBWJC-3547

Application*: WB, IH, F

Mouse Anti-CYP2A6 Recombinant Antibody (CBWJC-3548) (CBMAB-C4781WJ)

SDS

Target: CYP2A6

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBWJC-3548

Application*: WB, IH, IF, F

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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