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Rabbit Anti-CYP2C19 Recombinant Antibody (CBWJC-3552) (CBMAB-C4786WJ)

This product is a Rabbit antibody that recognizes CYP2C19. This antibody CBWJC-3552 can be used for immunoassay techniques such as: WB, IP, FC, ICC.
See all CYP2C19 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBWJC-3552
Antibody Isotype
IgG
Application
WB, IP, FC, ICC

Basic Information

Specificity
Human
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
1.248 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cytochrome P450 Family 2 Subfamily C Member 19
Introduction
CYP2C19 (Cytochrome P450 Family 2 Subfamily C Member 19) is a Protein Coding gene. Diseases associated with CYP2C19 include Drug Metabolism, Poor, Cyp2c19-Related and Voriconazole Toxicity. Among its related pathways are Gefitinib Pathway, Pharmacokinetics and superpathway of tryptophan utilization. Gene Ontology (GO) annotations related to this gene include enzyme binding and iron ion binding. An important paralog of this gene is CYP2C9.
Entrez Gene ID
1557
UniProt ID
P33261
Alternative Names
Cytochrome P450 Family 2 Subfamily C Member 19; Cytochrome P450, Subfamily IIC (Mephenytoin 4-Hydroxylase), Polypeptide 19; Cytochrome P450, Family 2, Subfamily C, Polypeptide 19; (R)-Limonene 6-Monooxygenase; (S)-Limonene 6-Monooxygenase; (S)-Limonene 7-Monooxygenase; Mephenytoin 4-Hydroxylase; Cytochrome P450-254C; Cytochrome P450-11A; CYPIIC17; CYPIIC19; Flavoprotein-Linked Monooxygenase; S-Mephenytoin 4-Hydroxylase; Microsomal Monooxygenase;
Function
A cytochrome P450 monooxygenase involved in the metabolism of polyunsaturated fatty acids (PUFA) (PubMed:18577768, PubMed:19965576, PubMed:20972997).

Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:18577768, PubMed:19965576, PubMed:20972997).

Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates PUFA specifically at the omega-1 position (PubMed:18577768).

Catalyzes the epoxidation of double bonds of PUFA (PubMed:20972997, PubMed:19965576).

Also metabolizes plant monoterpenes such as limonene. Oxygenates (R)- and (S)-limonene to produce carveol and perillyl alcohol (PubMed:11950794).

Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine. Hydroxylates fenbendazole at the 4' position (PubMed:23959307).
Biological Process
Drug metabolic process Source: BHF-UCL
Epoxygenase P450 pathway Source: GO_Central
Exogenous drug catabolic process Source: BHF-UCL
Heterocycle metabolic process Source: BHF-UCL
Monoterpenoid metabolic process Source: BHF-UCL
Omega-hydroxylase P450 pathway Source: Reactome
Organic acid metabolic process Source: GO_Central
Steroid metabolic process Source: BHF-UCL
Xenobiotic metabolic process Source: GO_Central
Cellular Location
Endoplasmic reticulum membrane; Microsome membrane

Botton, M. R., Whirl‐Carrillo, M., Del Tredici, A. L., Sangkuhl, K., Cavallari, L. H., Agúndez, J. A., ... & Gaedigk, A. (2021). PharmVar GeneFocus: CYP2C19. Clinical Pharmacology & Therapeutics, 109(2), 352-366.

Koopmans, A. B., Braakman, M. H., Vinkers, D. J., Hoek, H. W., & van Harten, P. N. (2021). Meta-analysis of probability estimates of worldwide variation of CYP2D6 and CYP2C19. Translational psychiatry, 11(1), 1-16.

Wang, Y., Meng, X., Wang, A., Xie, X., Pan, Y., Johnston, S. C., ... & Wang, B. (2021). Ticagrelor versus clopidogrel in CYP2C19 loss-of-function carriers with stroke or TIA. New England Journal of Medicine, 385(27), 2520-2530.

Pratt, V. M., Del Tredici, A. L., Hachad, H., Ji, Y., Kalman, L. V., Scott, S. A., & Weck, K. E. (2018). Recommendations for clinical CYP2C19 genotyping allele selection: a report of the association for molecular pathology. The Journal of Molecular Diagnostics, 20(3), 269-276.

Cavallari, L. H., Lee, C. R., Beitelshees, A. L., Cooper-DeHoff, R. M., Duarte, J. D., Voora, D., ... & IGNITE Network. (2018). Multisite investigation of outcomes with implementation of CYP2C19 genotype-guided antiplatelet therapy after percutaneous coronary intervention. JACC: Cardiovascular Interventions, 11(2), 181-191.

Dean, L. (2018). Clopidogrel therapy and CYP2C19 genotype. Medical Genetics Summaries [Internet].

El Rouby, N., Lima, J. J., & Johnson, J. A. (2018). Proton pump inhibitors: from CYP2C19 pharmacogenetics to precision medicine. Expert opinion on drug metabolism & toxicology, 14(4), 447-460.

Jukić, M. M., Haslemo, T., Molden, E., & Ingelman-Sundberg, M. (2018). Impact of CYP2C19 genotype on escitalopram exposure and therapeutic failure: a retrospective study based on 2,087 patients. American Journal of Psychiatry, 175(5), 463-470.

Empey, P. E., Stevenson, J. M., Tuteja, S., Weitzel, K. W., Angiolillo, D. J., Beitelshees, A. L., ... & IGNITE Network. (2018). Multisite investigation of strategies for the implementation of CYP2C19 genotype‐guided antiplatelet therapy. Clinical Pharmacology & Therapeutics, 104(4), 664-674.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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