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Mouse Anti-CYP2S1 Recombinant Antibody (CBWJC-3570) (CBMAB-C4804WJ)

This product is a Mouse antibody that recognizes CYP2S1. This antibody CBWJC-3570 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all CYP2S1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBWJC-3570
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cytochrome P450 Family 2 Subfamily S Member 1
Introduction
CYP2S1 (Cytochrome P450 Family 2 Subfamily S Member 1) is a Protein Coding gene. Among its related pathways are superpathway of tryptophan utilization and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP1B1.
Entrez Gene ID
29785
UniProt ID
Q96SQ9
Alternative Names
Cytochrome P450 Family 2 Subfamily S Member 1; Cytochrome P450, Family 2, Subfamily S, Polypeptide 1; EC 1.14.14.1; CYPIIS1; Cytochrome P450, Subfamily IIS, Polypeptide 1; Cytochrome P540, Subfamily IIS, Polypeptide 1; Cytochrome P450 2S1;
Function
A cytochrome P450 monooxygenase involved in the metabolism of retinoids and eicosanoids (PubMed:12711469, PubMed:21068195).

In epidermis, may contribute to the oxidative metabolism of all-trans-retinoic acid. For this activity, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:12711469).

Additionally, displays peroxidase and isomerase activities toward various oxygenated eicosanoids such as prostaglandin H2 (PGH2) and hydroperoxyeicosatetraenoates (HPETEs) (PubMed:21068195).

Independently of cytochrome P450 reductase, NADPH, and O2, catalyzes the breakdown of PGH2 to hydroxyheptadecatrienoic acid (HHT) and malondialdehyde (MDA), which is known to act as a mediator of DNA damage (PubMed:21068195).
Biological Process
Epoxygenase P450 pathway Source: GO_Central
Exogenous drug catabolic process Source: GO_Central
Icosanoid metabolic process Source: UniProtKB
Organic acid metabolic process Source: GO_Central
Prostaglandin metabolic process Source: UniProtKB
Retinoic acid metabolic process Source: UniProtKB
Xenobiotic metabolic process Source: GO_Central
Cellular Location
Endoplasmic reticulum membrane; Microsome membrane

Cabrera‐Cano, A., Dávila‐Borja, V. M., Juárez‐Méndez, S., Marcial‐Quino, J., Gómez‐Manzo, S., & Castillo‐Rodríguez, R. A. (2021). Hypoxia as a modulator of cytochromes P450: Overexpression of the cytochromes CYP2S1 and CYP24A1 in human liver cancer cells in hypoxia. Cell Biochemistry and Function, 39(4), 478-487.

Guo, H., Zeng, B., Wang, L., Ge, C., Zuo, X., Li, Y., ... & Zhang, P. (2021). Knockdown CYP2S1 inhibits lung cancer cells proliferation and migration. Cancer Biomarkers, (Preprint), 1-9.

Sheng, Y., Wen, L., Zheng, X., Li, M., Wang, D., Chen, S., ... & Zhou, F. (2021). CYP2S1 might regulate proliferation and immune response of keratinocyte in psoriasis. Epigenetics, 16(6), 618-628.

Guo, W. W., Feng, M. M., Li, S. F., & Wei, L. H. (2021). Circular RNA circ_0023404 serves as a miR‐636 sponge to promote malignant behaviors in cervical cancer cells through upregulation of CYP2S1. The Kaohsiung Journal of Medical Sciences.

Li, Y., Su, X., Feng, C., Liu, S., Guan, H., Sun, Y., ... & Hou, P. (2020). CYP2S1 is a synthetic lethal target in BRAFV600E-driven thyroid cancers. Signal transduction and targeted therapy, 5(1), 1-12.

Khor, C. Y., & Khoo, B. Y. (2020). PPARα plays an important role in the migration activity, and the expression of CYP2S1 and CYP1B1 in chrysin-treated HCT116 cells. Biotechnology letters, 42(8), 1581-1595.

Szaefer, H., Licznerska, B., Cykowiak, M., & Baer-Dubowska, W. (2019). Expression of CYP2S1 and CYP2W1 in breast cancer epithelial cells and modulation of their expression by synthetic methoxy stilbenes. Pharmacological Reports, 71(6), 1001-1005.

Yan, P., Eng, O. C., & Yu, C. J. (2018). A review on the expression and metabolic features of orphan human cytochrome P450 2S1 (CYP2S1). Current Drug Metabolism, 19(11), 917-929.

Kang, X., Shi, H., Zhang, L., Wang, Y., Zhang, T., Han, M., ... & Wang, H. (2018). Genetic polymorphisms of CYP2S1, CYP2J2 and CYP2R1 genes in three Chinese populations: Han, Tibetan and Uighur. Pharmacogenomics, 19(12), 961-977.

Singh, N. K., White, S. R., Kalagara, S., & Kadavakollu, S. (2017). Inhibition of CYP2S1 mediated metabolism of anticancer prodrug AQ4N by liarozole. Journal of Applied Pharmaceutical Science, 7(02), 001-007.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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