CYP2S1

CYP2S1 (Cytochrome P450 Family 2 Subfamily S Member 1) is a Protein Coding gene. Among its related pathways are superpathway of tryptophan utilization and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP1B1.

Full Name

Cytochrome P450 Family 2 Subfamily S Member 1

Function

A cytochrome P450 monooxygenase involved in the metabolism of retinoids and eicosanoids (PubMed:12711469, PubMed:21068195).

In epidermis, may contribute to the oxidative metabolism of all-trans-retinoic acid. For this activity, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:12711469).

Additionally, displays peroxidase and isomerase activities toward various oxygenated eicosanoids such as prostaglandin H2 (PGH2) and hydroperoxyeicosatetraenoates (HPETEs) (PubMed:21068195).

Independently of cytochrome P450 reductase, NADPH, and O2, catalyzes the breakdown of PGH2 to hydroxyheptadecatrienoic acid (HHT) and malondialdehyde (MDA), which is known to act as a mediator of DNA damage (PubMed:21068195).

Biological Process

Epoxygenase P450 pathway Source: GO_Central
Exogenous drug catabolic process Source: GO_Central
Icosanoid metabolic process Source: UniProtKB
Organic acid metabolic process Source: GO_Central
Prostaglandin metabolic process Source: UniProtKB
Retinoic acid metabolic process Source: UniProtKB
Xenobiotic metabolic process Source: GO_Central

Cellular Location

Endoplasmic reticulum membrane; Microsome membrane