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Rat Anti-CYTH1 Recombinant Antibody (10H4) (CBMAB-C2354-LY)

This product is antibody recognizes CYTH1. The antibody 10H4 immunoassay techniques such as: WB, IP, IF.
See all CYTH1 antibodies

Summary

Host Animal
Rat
Specificity
Human
Clone
10H4
Antibody Isotype
IgG1, κ
Application
WB, IP, IF

Basic Information

Immunogen
Recognizes human Cytohesin-1
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Preservative
0.05% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Cytohesin 1
Introduction
CYTH1 (Cytohesin 1) is a Protein Coding gene. Among its related pathways are Vesicle-mediated transport and Endocytosis. Gene Ontology (GO) annotations related to this gene include lipid binding and ARF guanyl-nucleotide exchange factor activity. An important paralog of this gene is CYTH3.
Entrez Gene ID
9267
UniProt ID
Q15438
Alternative Names
Cytohesin 1; PH, SEC7 And Coiled-Coil Domain-Containing Protein 1; Pleckstrin Homology, Sec7 And Coiled-Coil Domains 1; SEC7 Homolog B2-1; D17S811E; PSCD1;
Function
Promotes guanine-nucleotide exchange on ARF1, ARF5 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization, through regulation of ARF6 activity.
Biological Process
Establishment of epithelial cell polarity Source: UniProtKB
Regulation of ARF protein signal transduction Source: InterPro
Regulation of cell adhesion Source: MGI
Vesicle-mediated transport Source: ProtInc
Cellular Location
Cell membrane; Cytosol; Tight junction; Adherens junction. Colocalized with TJP1 during epithelial polarization.
PTM
Ubiquitinated by SCF(FBXW11) E3 ubiquitin-protein ligase complex. Ubiquitination induces proteasomal degradation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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