CYTH1
CYTH1 (Cytohesin 1) is a Protein Coding gene. Among its related pathways are Vesicle-mediated transport and Endocytosis. Gene Ontology (GO) annotations related to this gene include lipid binding and ARF guanyl-nucleotide exchange factor activity. An important paralog of this gene is CYTH3.
Full Name
Cytohesin 1
Function
Promotes guanine-nucleotide exchange on ARF1, ARF5 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization, through regulation of ARF6 activity.
Biological Process
Establishment of epithelial cell polarity Source: UniProtKB
Regulation of ARF protein signal transduction Source: InterPro
Regulation of cell adhesion Source: MGI
Vesicle-mediated transport Source: ProtInc
Regulation of ARF protein signal transduction Source: InterPro
Regulation of cell adhesion Source: MGI
Vesicle-mediated transport Source: ProtInc
Cellular Location
Cell membrane; Cytosol; Tight junction; Adherens junction. Colocalized with TJP1 during epithelial polarization.
PTM
Ubiquitinated by SCF(FBXW11) E3 ubiquitin-protein ligase complex. Ubiquitination induces proteasomal degradation.
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Anti-CYTH1 antibodies
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Target: CYTH1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6G11
Application*: WB, IF, IP, P
Target: CYTH1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-2582
Application*: WB, IP, IF, E
Target: CYTH1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2E11
Application*: WB, F, IF
Target: CYTH1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1D6
Application*: E, IF, P, WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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