CYTH1

CYTH1 (Cytohesin 1) is a Protein Coding gene. Among its related pathways are Vesicle-mediated transport and Endocytosis. Gene Ontology (GO) annotations related to this gene include lipid binding and ARF guanyl-nucleotide exchange factor activity. An important paralog of this gene is CYTH3.

Full Name

Cytohesin 1

Function

Promotes guanine-nucleotide exchange on ARF1, ARF5 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization, through regulation of ARF6 activity.

Biological Process

Establishment of epithelial cell polarity Source: UniProtKB
Regulation of ARF protein signal transduction Source: InterPro
Regulation of cell adhesion Source: MGI
Vesicle-mediated transport Source: ProtInc

Cellular Location

Cell membrane; Cytosol; Tight junction; Adherens junction. Colocalized with TJP1 during epithelial polarization.

PTM

Ubiquitinated by SCF(FBXW11) E3 ubiquitin-protein ligase complex. Ubiquitination induces proteasomal degradation.

Anti-CYTH1 antibodies

Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Mouse Anti-CYTH1 Recombinant Antibody (6G11) (CBMAB-C8302-LY)

Datasheet

SDS

Target: CYTH1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 6G11

Application*: WB, IF, IP, P

Mouse Anti-CYTH1 Recombinant Antibody (CBFYC-2582) (V2LY-0125-LY1025)

Datasheet

SDS

Target: CYTH1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYC-2582

Application*: WB, IP, IF, E

Mouse Anti-CYTH1 Recombinant Antibody (2E11) (V2LY-0125-LY1023)

Datasheet

SDS

Target: CYTH1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 2E11

Application*: WB, F, IF

Mouse Anti-CYTH1 Recombinant Antibody (1D6) (V2LY-0125-LY1022)

Datasheet

SDS

Target: CYTH1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 1D6

Application*: E, IF, P, WB

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)