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Mouse Anti-CYTH2 Recombinant Antibody (CBCNC-582) (CBMAB-C3339-CN)

This product is a Mouse antibody that recognizes CYTH2. The antibody CBCNC-582 can be used for immunoassay techniques such as: ELISA, ICC, IHC, WB.
See all CYTH2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBCNC-582
Antibody Isotype
IgG2a
Application
ELISA, ICC, IHC, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2
Preservative
0.09% Sodium azide

Target

Full Name
cytohesin 2
Introduction
CYTH2 (Cytohesin 2) is a Protein Coding gene. Diseases associated with CYTH2 include Neuroblastoma. Among its related pathways are Vesicle-mediated transport and Endocytosis. Gene Ontology (GO) annotations related to this gene include lipid binding and inositol 1,4,5 trisphosphate binding. An important paralog of this gene is CYTH1.
Entrez Gene ID
9266
UniProt ID
Q99418
Alternative Names
Cytohesin 2; Pleckstrin Homology, Sec7 And Coiled/Coil Domains 2 (Cytohesin-2); PH, SEC7 And Coiled-Coil Domain-Containing Protein 2; Pleckstrin Homology, Sec7 And Coiled-Coil Domains 2; ARF Nucleotide-Binding Site Opener; ARF Exchange Factor; PSCD2L; PSCD2; ARNO;
Function
Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Activates ARF factors through replacement of GDP with GTP (By similarity).

The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane (PubMed:17398095).

Involved in neurite growth (By similarity).
Biological Process
Actin cytoskeleton organization Source: ProtInc
Endocytosis Source: ProtInc
Regulation of ARF protein signal transduction Source: InterPro
Cellular Location
Cytoplasm; Cell membrane; Cell projection; Growth cone; Tight junction; Adherens junction. Both isoform 1 and isoform 2 are recruited to the cell membrane through its association with ARL4A, ARL4C and ARL4D. They require also interaction with phosphoinositides for targeting to plasma membrane (PubMed:17398095). In differentiating neuroblastoma cells, colocalizes with CCDC120 in both neurite shaft and growth cone areas.

Yi, C., Cai, C., Cheng, Z., Zhao, Y., Yang, X., Wu, Y., ... & Zhang, A. (2022). Genome-wide CRISPR-Cas9 screening identifies the CYTH2 host gene as a potential therapeutic target of influenza viral infection. Cell Reports, 38(13), 110559.

Miyamoto, Y., Torii, T., Homma, K., Oizumi, H., Ohbuchi, K., Mizoguchi, K., ... & Yamauchi, J. (2022). The adaptor SH2B1 and the phosphatase PTP4A1 regulate the phosphorylation of cytohesin-2 in myelinating Schwann cells in mice. Science Signaling, 15(718), eabi5276.

Wang, Y., Cil, C., Harnett, M. M., & Pineda, M. (2021). GEF Cytohesin-2/ARNO: a novel bridge between cell migration and immunoregulation in synovial fibroblasts. bioRxiv.

Ito, H., Morishita, R., Noda, M., Ishiguro, T., Nishikawa, M., & Nagata, K. I. (2021). The synaptic scaffolding protein CNKSR2 interacts with CYTH2 to mediate hippocampal granule cell development. Journal of Biological Chemistry, 297(6).

Heun, Y., Gräff, P., Lagara, A., Schelhorn, R., Mettler, R., Pohl, U., & Mannell, H. (2020). The GEF Cytohesin-2/ARNO mediates resistin induced phenotypic switching in vascular smooth muscle cells. Scientific reports, 10(1), 1-10.

Namislo, A. M. (2019). The differential regulation of podosome formation by Cytohesin-2 is mediated via α5β1 integrin and the small GTPase RhoA.

Ito, A., Fukaya, M., Saegusa, S., Kobayashi, E., Sugawara, T., Hara, Y., ... & Sakagami, H. (2018). Pallidin is a novel interacting protein for cytohesin‐2 and regulates the early endosomal pathway and dendritic formation in neurons. Journal of Neurochemistry, 147(2), 153-177.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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