CYTH2

The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. The encoded protein exhibits GEP activity in vitro with ARF1, ARF3, and ARF6 and is 83% homologous to CYTH1. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
Full Name
cytohesin 2
Function
Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Activates ARF factors through replacement of GDP with GTP (By similarity).

The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane (PubMed:17398095).

Involved in neurite growth (By similarity).
Biological Process
Actin cytoskeleton organization Source: ProtInc
Endocytosis Source: ProtInc
Regulation of ARF protein signal transduction Source: InterPro
Cellular Location
Cytoplasm; Cell membrane; Cell projection; Growth cone; Tight junction; Adherens junction. Both isoform 1 and isoform 2 are recruited to the cell membrane through its association with ARL4A, ARL4C and ARL4D. They require also interaction with phosphoinositides for targeting to plasma membrane (PubMed:17398095). In differentiating neuroblastoma cells, colocalizes with CCDC120 in both neurite shaft and growth cone areas.
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Anti-CYTH2 antibodies

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Mouse Anti-CYTH2 Recombinant Antibody (CBFYC-2583) (CBMAB-C2657-FY)

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Target: CYTH2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBFYC-2583
Application*: WB, IF, IP, P
Datasheet SDS

Mouse Anti-CYTH2 Recombinant Antibody (CBCNC-581) (V2LY-0125-LY1031)

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Target: CYTH2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat
Clone: CBCNC-581
Application*: WB, P, IF
Datasheet SDS

Mouse Anti-CYTH2 Recombinant Antibody (C4820WJ) (V2LY-0125-LY1030)

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Target: CYTH2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: C4820WJ
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-CYTH2 Recombinant Antibody (CBXC-2916) (V2LY-0125-LY1029)

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Target: CYTH2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat, Horse, Dog, Cattle, Pig
Clone: CBXC-2916
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-CYTH2 Recombinant Antibody (6H5) (V2LY-0125-LY1027)

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Target: CYTH2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Rat
Clone: 6H5
Application*: E, IF, WB, P
Datasheet SDS

Mouse Anti-CYTH2 Recombinant Antibody (5E11) (V2LY-0125-LY1026)

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Target: CYTH2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 5E11
Application*: E, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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