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Mouse Anti-DBF4B Recombinant Antibody (1A7) (CBMAB-D0286-YC)

Provided herein is a Mouse monoclonal antibody, which binds to DBF4 Zinc Finger B (DBF4B). The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all DBF4B antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1A7
Antibody Isotype
IgG1, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant corresponding to a.a.201-300 from human DBF4B (NP_663696) with GST tag.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
DBF4 homolog B (S. cerevisiae)
Introduction
DBF4B is a regulator of the cell division cycle 7 homolog (S. cerevisiae) protein, a serine-threonine kinase which links cell cycle regulation to genome duplication. This protein localizes to the nucleus and, in complex with the cell division cycle 7 homolog (S. cerevisiae) protein, may facilitate M phase progression.
Entrez Gene ID
80174
UniProt ID
Q8NFT6
Alternative Names
DBF4 Zinc Finger B; Zinc Finger, DBF-Type Containing 1B; Dbf4-Related Factor 1; ASK-Like Protein 1; Chiffon Homolog B; ASKL1; DRF1; Activator Of S-Phase Kinase-Like Protein 1;
Function
Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S and M phases. The complex CDC7-DBF4B selectively phosphorylates MCM2 subunit at 'Ser-40' and then is involved in regulating the initiation of DNA replication during cell cycle.
Biological Process
Cell cycle Source: UniProtKB-KW
Positive regulation of cell population proliferation Source: UniProtKB
Positive regulation of G2/M transition of mitotic cell cycle Source: UniProtKB
Positive regulation of nuclear cell cycle DNA replication Source: UniProtKB
Regulation of cell cycle phase transition Source: GO_Central
Cellular Location
Nucleus. Predominantly found in soluble fraction but not in the chromatin-bound fraction.
PTM
Phosphorylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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