DBF4B

This gene encodes a regulator of the CDC7-like 1 protein, a serine-threonine kinase which links cell cycle regulation to genome duplication. This protein localizes to the nucleus and its expression is cell cycle-regulated. Alternative splicing of this gene results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full length sequences have not been determined. [provided by RefSeq]

Full Name

DBF4 homolog B (S. cerevisiae)

Function

Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S and M phases. The complex CDC7-DBF4B selectively phosphorylates MCM2 subunit at 'Ser-40' and then is involved in regulating the initiation of DNA replication during cell cycle.

Biological Process

Cell cycle Source: UniProtKB-KW
Positive regulation of cell population proliferation Source: UniProtKB
Positive regulation of G2/M transition of mitotic cell cycle Source: UniProtKB
Positive regulation of nuclear cell cycle DNA replication Source: UniProtKB
Regulation of cell cycle phase transition Source: GO_Central

Cellular Location

Nucleus. Predominantly found in soluble fraction but not in the chromatin-bound fraction.

PTM

Phosphorylated.