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Mouse Anti-DBNL Recombinant Antibody (CBXS-5808) (CBMAB-S0664-CQ)

This product is a mouse antibody that recognizes DBNL. The antibody CBXS-5808 can be used for immunoassay techniques such as: IHC-P.
See all DBNL antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-5808
Antibody Isotype
IgG1
Application
IHC-P

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Drebrin Like
Introduction
DBNL (Drebrin Like) is a Protein Coding gene. Among its related pathways are Innate Immune System and Transmission across Chemical Synapses. Gene Ontology (GO) annotations related to this gene include actin binding and protein C-terminus binding. An important paralog of this gene is DBN1.
Entrez Gene ID
28988
UniProt ID
Q9UJU6
Alternative Names
Drebrin Like; HPK1-Interacting Protein Of 55 KDa; Cervical Mucin-Associated Protein; SH3 Domain-Containing Protein 7; Actin-Binding Protein 1; Cervical SH3P7; Drebrin-F; HIP-55;
Function
Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes (By similarity).

May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes.
Biological Process
Activation of JUN kinase activity Source: ProtInc
Adaptive immune response Source: UniProtKB-KW
Neuron projection morphogenesis Source: UniProtKB
Neutrophil degranulation Source: Reactome
Podosome assembly Source: UniProtKB
Positive regulation of axon extension Source: GO_Central
Positive regulation of dendritic spine morphogenesis Source: GO_Central
Postsynaptic actin cytoskeleton organization Source: GO_Central
Rac protein signal transduction Source: UniProtKB
Receptor-mediated endocytosis Source: InterPro
Regulation of actin filament polymerization Source: GO_Central
Ruffle assembly Source: InterPro
Synapse assembly Source: UniProtKB
Cellular Location
Cell membrane; Golgi apparatus membrane; Early endosome; Cytosol; Cytoskeleton; Lamellipodium; Ruffle; Cell cortex; Synapse; Perikaryon; Neuron projection; Clathrin-coated vesicle membrane; Podosome; Dendrite; Postsynaptic density. Associates with lamellipodial actin and membrane ruffles. Colocalizes with actin and cortactin at podosome dots and podosome rosettes.
PTM
Degraded by caspases during apoptosis.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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