DBNL

DBNL (Drebrin Like) is a Protein Coding gene. Among its related pathways are Innate Immune System and Transmission across Chemical Synapses. Gene Ontology (GO) annotations related to this gene include actin binding and protein C-terminus binding. An important paralog of this gene is DBN1.

Full Name

Drebrin Like

Function

Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes (By similarity).

May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes.

Biological Process

Activation of JUN kinase activity Source: ProtInc
Adaptive immune response Source: UniProtKB-KW
Neuron projection morphogenesis Source: UniProtKB
Neutrophil degranulation Source: Reactome
Podosome assembly Source: UniProtKB
Positive regulation of axon extension Source: GO_Central
Positive regulation of dendritic spine morphogenesis Source: GO_Central
Postsynaptic actin cytoskeleton organization Source: GO_Central
Rac protein signal transduction Source: UniProtKB
Receptor-mediated endocytosis Source: InterPro
Regulation of actin filament polymerization Source: GO_Central
Ruffle assembly Source: InterPro
Synapse assembly Source: UniProtKB

Cellular Location

Cell membrane; Golgi apparatus membrane; Early endosome; Cytosol; Cytoskeleton; Lamellipodium; Ruffle; Cell cortex; Synapse; Perikaryon; Neuron projection; Clathrin-coated vesicle membrane; Podosome; Dendrite; Postsynaptic density. Associates with lamellipodial actin and membrane ruffles. Colocalizes with actin and cortactin at podosome dots and podosome rosettes.

PTM

Degraded by caspases during apoptosis.