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Mouse Anti-DCSTAMP Recombinant Antibody (CBYCD-184) (CBMAB-D0397-YC)

Provided herein is a Mouse monoclonal antibody, which binds to Dendrocyte Expressed Seven Transmembrane Protein (DCSTAMP). The antibody can be used for immunoassay techniques, such as FC.
See all DCSTAMP antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYCD-184
Antibody Isotype
IgG2b
Application
FC

Basic Information

Immunogen
E. coli-derived recombinant human DC-STAMP, Asp314-Thr376, Accession # Q9H295
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Dendrocyte Expressed Seven Transmembrane Protein
Introduction
DCSTAMP is a seven-pass transmembrane protein that is primarily expressed in dendritic cells. DCSTAMP is involved in a range of immunological functions carried out by dendritic cells. This protein plays a role in osteoclastogenesis and myeloid differentiation.
Entrez Gene ID
81501
UniProt ID
Q9H295
Alternative Names
Dendrocyte Expressed Seven Transmembrane Protein; Transmembrane 7 Superfamily Member 4; Dendritic Cells (DC)-Specific Transmembrane Protein; IL-Four-Induced Protein; IL-Four INDuced; HDC-STAMP; TM7SF4; FIND;
Function
Probable cell surface receptor that plays several roles in cellular fusion, cell differentiation, bone and immune homeostasis. Plays a role in TNFSF11-mediated osteoclastogenesis. Cooperates with OCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Participates in osteoclast bone resorption. Involved in inducing the expression of tartrate-resistant acid phosphatase in osteoclast precursors. Plays a role in haematopoietic stem cell differentiation of bone marrow cells toward the myeloid lineage. Inhibits the development of neutrophilic granulocytes. Plays also a role in the regulation of dendritic cell (DC) antigen presentation activity by controlling phagocytic activity. Involved in the maintenance of immune self-tolerance and avoidance of autoimmune reactions.
Biological Process
Cellular response to interleukin-4 Source: UniProtKB
Cellular response to macrophage colony-stimulating factor stimulus Source: UniProtKB
Cellular response to tumor necrosis factor Source: UniProtKB
Membrane fusion Source: UniProtKB
Myeloid dendritic cell differentiation Source: UniProtKB
Negative regulation of cell growth Source: UniProtKB
Osteoclast differentiation Source: UniProtKB
Osteoclast fusion Source: UniProtKB
Positive regulation of bone resorption Source: UniProtKB
Positive regulation of macrophage fusion Source: UniProtKB
Positive regulation of monocyte differentiation Source: UniProtKB
Cellular Location
Endosome; Endoplasmic reticulum membrane; Cell membrane; Endoplasmic reticulum-Golgi intermediate compartment membrane. Localizes to the cell surface in osteoclasts and undifferentiated monocytes. Intracellular internalized DCSTAMP is detected in a fraction of RANKL-induced osteoclast precursor. Colocalizes with OS9 in the endoplasmic reticulum (ER) of immature dendritic cell (DC). Translocates from the endoplasmic reticulum to the intermediate/Golgi compartment upon maturation of DC in a OS9-dependent manner. Colocalizes with LAMP1 in endosomes (By similarity).
Topology
Cytoplasmic: 1-34
Helical: 35-55
Extracellular: 56-57
Helical: 58-78
Cytoplasmic: 79-97
Helical: 98-118
Extracellular: 119-209
Helical: 210-230
Cytoplasmic: 231-292
Helical: 293-313
Extracellular: 314-376
Helical: 377-397
Cytoplasmic: 398-470
PTM
Glycosylated.

Zou, B. H., Tan, Y. H., Deng, W. D., Zheng, J. H., Yang, Q., Ke, M. H., ... & Li, X. J. (2021). Oridonin ameliorates inflammation-induced bone loss in mice via suppressing DC-STAMP expression. Acta Pharmacologica Sinica, 42(5), 744-754.

Guardiola, C. J. D. A., Clemente-Napimoga, J. T., Martinez, E. F., Abdalla, H. B., Peruzzo, D. C., Joly, J. C., & Napimoga, M. H. (2020). DC-STAMP and TACE Levels are Higher in Patients with Periodontitis. Brazilian Dental Journal, 31, 122-126.

Møller, A. M., Delaissé, J. M., Olesen, J. B., Canto, L. M., Rogatto, S. R., Madsen, J. S., & Søe, K. (2020). Fusion potential of human osteoclasts in vitro reflects age, menopause, and in vivo bone resorption levels of their donors—a possible involvement of DC-STAMP. International journal of molecular sciences, 21(17), 6368.

Kuriya, K., Nishio, M., Matsuda, T., & Umekawa, H. (2020). Tea extract increases cell fusion via regulation of cell surface DC-STAMP. Biochemistry and Biophysics Reports, 22, 100759.

Mullin, B. H., Zhu, K., Brown, S. J., Mullin, S., Tickner, J., Pavlos, N. J., ... & Wilson, S. G. (2019). Genetic regulatory mechanisms in human osteoclasts suggest a role for the STMP1 and DCSTAMP genes in Paget’s disease of bone. Scientific reports, 9(1), 1-7.

Takagi, T., Inoue, H., Takahashi, N., Katsumata-Tsuboi, R., & Uehara, M. (2017). Sulforaphane inhibits osteoclast differentiation by suppressing the cell-cell fusion molecules DC-STAMP and OC-STAMP. Biochemical and biophysical research communications, 483(1), 718-724.

Yin, Y., Tang, L., Chen, J., & Lu, X. (2017). MiR-30a attenuates osteoclastogenesis via targeting DC-STAMP-c-Fos-NFATc1 signaling. American Journal of Translational Research, 9(12), 5743.

Chiu, Y. H., Schwarz, E., Li, D., Xu, Y., Sheu, T. R., Li, J., ... & Ritchlin, C. T. (2017). Dendritic cell‐specific transmembrane protein (DC‐STAMP) regulates osteoclast differentiation via the Ca2+/NFATc1 axis. Journal of cellular physiology, 232(9), 2538-2549.

Wisitrasameewong, W., Kajiya, M., Movila, A., Rittling, S., Ishii, T., Suzuki, M., ... & Kawai, T. (2017). DC-STAMP is an osteoclast fusogen engaged in periodontal bone resorption. Journal of dental research, 96(6), 685-693.

Takagi, T., Inoue, H., Takahashi, N., Katsumata-Tsuboi, R., & Uehara, M. (2017). Sulforaphene attenuates multinucleation of pre-osteoclasts by suppressing expression of cell–cell fusion-associated genes DC-STAMP, OC-STAMP, and Atp6v0d2. Bioscience, Biotechnology, and Biochemistry, 81(6), 1220-1223.

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For research use only. Not intended for any clinical use.

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