DCSTAMP

DCSTAMP is a seven-pass transmembrane protein that is primarily expressed in dendritic cells. DCSTAMP is involved in a range of immunological functions carried out by dendritic cells. This protein plays a role in osteoclastogenesis and myeloid differentiation.

Full Name

Dendrocyte Expressed Seven Transmembrane Protein

Function

Probable cell surface receptor that plays several roles in cellular fusion, cell differentiation, bone and immune homeostasis. Plays a role in TNFSF11-mediated osteoclastogenesis. Cooperates with OCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Participates in osteoclast bone resorption. Involved in inducing the expression of tartrate-resistant acid phosphatase in osteoclast precursors. Plays a role in haematopoietic stem cell differentiation of bone marrow cells toward the myeloid lineage. Inhibits the development of neutrophilic granulocytes. Plays also a role in the regulation of dendritic cell (DC) antigen presentation activity by controlling phagocytic activity. Involved in the maintenance of immune self-tolerance and avoidance of autoimmune reactions.

Biological Process

Cellular response to interleukin-4 Source: UniProtKB
Cellular response to macrophage colony-stimulating factor stimulus Source: UniProtKB
Cellular response to tumor necrosis factor Source: UniProtKB
Membrane fusion Source: UniProtKB
Myeloid dendritic cell differentiation Source: UniProtKB
Negative regulation of cell growth Source: UniProtKB
Osteoclast differentiation Source: UniProtKB
Osteoclast fusion Source: UniProtKB
Positive regulation of bone resorption Source: UniProtKB
Positive regulation of macrophage fusion Source: UniProtKB
Positive regulation of monocyte differentiation Source: UniProtKB

Cellular Location

Endosome; Endoplasmic reticulum membrane; Cell membrane; Endoplasmic reticulum-Golgi intermediate compartment membrane. Localizes to the cell surface in osteoclasts and undifferentiated monocytes. Intracellular internalized DCSTAMP is detected in a fraction of RANKL-induced osteoclast precursor. Colocalizes with OS9 in the endoplasmic reticulum (ER) of immature dendritic cell (DC). Translocates from the endoplasmic reticulum to the intermediate/Golgi compartment upon maturation of DC in a OS9-dependent manner. Colocalizes with LAMP1 in endosomes (By similarity).

Topology

Cytoplasmic: 1-34
Helical: 35-55
Extracellular: 56-57
Helical: 58-78
Cytoplasmic: 79-97
Helical: 98-118
Extracellular: 119-209
Helical: 210-230
Cytoplasmic: 231-292
Helical: 293-313
Extracellular: 314-376
Helical: 377-397
Cytoplasmic: 398-470

PTM

Glycosylated.