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Rabbit Anti-DCTN4 Recombinant Antibody (CBYCD-189) (CBMAB-D0418-YC)

Provided herein is a Rabbit monoclonal antibody, which binds to Dynactin Subunit 4 (DCTN4). The antibody can be used for immunoassay techniques, such as WB, IHC-P, ICC, IF.
See all DCTN4 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
CBYCD-189
Antibody Isotype
IgG
Application
WB, IHC-P, ICC, IF

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
dynactin 4
Introduction
DCTN4 (Dynactin Subunit 4) is a protein coding gene. Diseases associated with DCTN4 include Cystic Fibrosis. Among its related pathways are COPI-independent Golgi-to-ER retrograde traffic and Transport to the Golgi and subsequent modification. It has proved that the protein has protein N-terminus binding.
Entrez Gene ID
Human51164
Mouse67665
Rat84428
UniProt ID
HumanQ9UJW0
MouseQ8CBY8
RatQ9QUR2
Alternative Names
Dynactin Subunit 4; Dynactin Subunit P62; Dynactin 4 (P62); DYN4; Dynactin P62 Subunit; P62;
Function
Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton.
Biological Process
Antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
Endoplasmic reticulum to Golgi vesicle-mediated transport Source: Reactome
Cellular Location
Cytoskeleton; Centrosome; Stress fiber; Cell cortex; sarcomere. Has a punctate cytoplasmic distribution as well as centrosomal distribution typical of dynactin (PubMed:10671518). Overexpression in cultured mammalian cells revealed colocalization with cortical actin, stress fibers, and focal adhesion sites, sites of potential interaction between microtubules and the cell cortex (By similarity). In skeletal muscles, costamere localization requires the presence of ANK2 (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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