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Mouse Anti-DDT Recombinant Antibody (CBYCD-210) (CBMAB-D0512-YC)

Provided herein is a Mouse monoclonal antibody, which binds to D-Dopachrome Tautomerase (DDT). The antibody can be used for immunoassay techniques, such as WB, ICC, IHC-P, IHC-Fr, ELISA.
See all DDT antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYCD-210
Antibody Isotype
IgG
Application
WB, ICC, IHC-P, IHC-Fr, ELISA

Basic Information

Immunogen
D-Dopachrome Tautomerase
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
D-dopachrome tautomerase
Introduction
DDT converts D-dopachrome into 5,6-dihydroxyindole. DDT is related to the migration inhibitory factor (MIF) in terms of sequence, enzyme activity, and gene structure.
Entrez Gene ID
1652
UniProt ID
P30046
Alternative Names
D-Dopachrome Tautomerase; Phenylpyruvate Tautomerase II; D-Dopachrome Decarboxylase; EC 4.1.1.84; DDCT;
Function
Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI).
Biological Process
Melanin biosynthetic process Source: UniProtKB-KW
Negative regulation of macrophage chemotaxis Source: BHF-UCL
Positive regulation of ERK1 and ERK2 cascade Source: BHF-UCL
Positive regulation of inflammatory response Source: BHF-UCL
Positive regulation of tumor necrosis factor production Source: BHF-UCL
Cellular Location
Cytoplasm

Caltabiano, R., De Pasquale, R., Piombino, E., Campo, G., Nicoletti, F., Cavalli, E., ... & Fagone, P. (2021). Macrophage Migration Inhibitory Factor (MIF) and Its Homologue D-Dopachrome Tautomerase (DDT) Inversely Correlate with Inflammation in Discoid Lupus Erythematosus. Molecules, 26(1), 184.

Song, S., Liu, B., Habibie, H., van den Bor, J., Smit, M. J., Gosens, R., ... & Melgert, B. N. (2021). D-dopachrome tautomerase contributes to lung epithelial repair via atypical chemokine receptor 3-dependent Akt signaling. EBioMedicine, 68, 103412.

Illescas, O., Pacheco-Fernández, T., Laclette, J. P., Rodriguez, T., & Rodriguez-Sosa, M. (2020). Immune modulation by the macrophage migration inhibitory factor (MIF) family: D-dopachrome tautomerase (DDT) is not (always) a backup system. Cytokine, 133, 155121.

Cavalli, E., Mazzon, E., Mammana, S., Basile, M. S., Lombardo, S. D., Mangano, K., ... & Petralia, M. C. (2019). Overexpression of macrophage migration inhibitory factor and its homologue d-dopachrome tautomerase as negative prognostic factor in neuroblastoma. Brain Sciences, 9(10), 284.

Ma, Y., Su, K. N., Pfau, D., Rao, V. S., Wu, X., Hu, X., ... & Young, L. H. (2019). Cardiomyocyte d-dopachrome tautomerase protects against heart failure. JCI insight, 4(17).

Cavalli, E., Mazzon, E., Basile, M. S., Mangano, K., Di Marco, R., Bramanti, P., ... & Petralia, M. C. (2019). Upregulated expression of macrophage migration inhibitory factor, its analogue D-dopachrome tautomerase, and the CD44 receptor in peripheral CD4 T cells from clinically isolated syndrome patients with rapid conversion to clinical defined multiple sclerosis. Medicina, 55(10), 667.

Han, Z., Qu, J., Zhao, J., & Zou, X. (2018). Genetic variant rs755622 regulates expression of the multiple sclerosis severity modifier D-dopachrome tautomerase in a sex-specific way. BioMed research international, 2018.

Vincent, F. B., Lin, E., Sahhar, J., Ngian, G. S., Kandane‐Rathnayake, R., Mende, R., ... & Harris, J. (2018). Analysis of serum macrophage migration inhibitory factor and D‐dopachrome tautomerase in systemic sclerosis. Clinical & translational immunology, 7(12), e1042.

Roger, T., Schlapbach, L. J., Schneider, A., Weier, M., Wellmann, S., Marquis, P., ... & Giannoni, E. (2017). Plasma levels of macrophage migration inhibitory factor and d-dopachrome tautomerase show a highly specific profile in early life. Frontiers in immunology, 8, 26.

Iwata, T., Kuribayashi, K., Nakasono, M., Saito-Tarashima, N., Minakawa, N., Mizusawa, N., ... & Yoshimoto, K. (2017). The AMPK/mTOR pathway is involved in D-dopachrome tautomerase gene transcription in adipocytes differentiated from SGBS cells, a human preadipocyte cell line. Cytokine, 96, 195-202.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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