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Mouse Anti-DEK Recombinant Antibody (2/DEK) (CBMAB-D0696-YC)

Provided herein is a Mouse monoclonal antibody, which binds to DEK Proto-Oncogene (DEK). The antibody can be used for immunoassay techniques, such as WB, IF.
See all DEK antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2/DEK
Antibody Isotype
IgG1
Application
WB, IF

Basic Information

Immunogen
Human DEK a.a.19-169
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
DEK Proto-Oncogene
Introduction
DEK is a protein with one SAP domain. This protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA, and is also involved in splice site selection during mRNA processing. Chromosomal aberrations involving this region, increased expression of this gene, and the presence of antibodies against this protein are all associated with various diseases. Two transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
7913
UniProt ID
P35659
Alternative Names
DEK Proto-Oncogene; DEK Oncogene (DNA Binding); DEK Oncogene; Protein DEK; D6S231E;
Function
Involved in chromatin organization.
Biological Process
Chromatin organization Source: UniProtKB-KW
Granulocyte differentiation Source: Reactome
Positive regulation of gene expression, epigenetic Source: Reactome
Regulation of double-strand break repair Source: MGI
Regulation of transcription by RNA polymerase II Source: Reactome
Signal transduction Source: ProtInc
Transcription by RNA polymerase II Source: ProtInc
Viral genome replication Source: ProtInc
Cellular Location
Nucleus. Enriched in regions where chromatin is decondensed or sparse in the interphase nuclei.
Involvement in disease
A chromosomal aberration involving DEK is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia (PubMed:1549122). Translocation t(6;9)(p23;q34) with NUP214/CAN (PubMed:1549122). It results in the formation of a DEK-NUP214 fusion gene (PubMed:1549122).
PTM
Phosphorylated by CK2. Phosphorylation fluctuates during the cell cycle with a moderate peak during G1 phase, and weakens the binding of DEK to DNA.

Yang, M. Q., Bai, L. L., Wang, Z., Lei, L., Zheng, Y. W., Li, Z. H., ... & Xu, H. T. (2021). DEK is highly expressed in breast cancer and is associated with malignant phenotype and progression. Oncology Letters, 21(6), 1-9.

Cai, Y., Hao, Y., Xu, H., Chen, K., & Ren, B. (2021). Gigantol inhibits cell proliferation and induces apoptosis by regulating DEK in non‑small cell lung cancer. Experimental and therapeutic medicine, 22(5), 1-9.

Yang, Y., Lin, H., Du, Z., Hu, R., Tang, Y., Liang, X., ... & Tan, Y. (2020). Imatinib therapy in acute myeloid leukemia with DEK‑NUP214 and FIP1L1‑PDGFRA rearrangement: A case report. Oncology Letters, 19(5), 3587-3592.

Liu, C. S., Zhou, Q., Zhang, Y. D., & Fu, Y. (2020). Long noncoding RNA SOX2OT maintains the stemness of pancreatic cancer cells by regulating DEK via interacting with miR-200a/141. European review for medical and pharmacological sciences, 24(23), 11991-11991.

Ishida, K., Nakashima, T., Shibata, T., Hara, A., & Tomita, H. (2020). Role of the DEK oncogene in the development of squamous cell carcinoma. International Journal of Clinical Oncology, 25(9), 1563-1569.

Matrka, M. C. (2017). Oncogenic Phenotypes Induced by Overexpression of the DEK Proto-oncogene (Doctoral dissertation, University of Cincinnati).

Xu, Y., Liang, Z., Li, C., Yang, Z., & Chen, L. (2017). LCMR1 interacts with DEK to suppress apoptosis in lung cancer cells. Molecular Medicine Reports, 16(4), 4159-4164.

Nakashima, T., Tomita, H., Hirata, A., Ishida, K., Hisamatsu, K., Hatano, Y., ... & Hara, A. (2017). Promotion of cell proliferation by the proto‐oncogene DEK enhances oral squamous cell carcinogenesis through field cancerization. Cancer medicine, 6(10), 2424-2439.

Feng, T., Liu, Y., Li, C., Li, Z., & Cai, H. (2017). DEK proto-oncogene is highly expressed in astrocytic tumors and regulates glioblastoma cell proliferation and apoptosis. Tumor Biology, 39(7), 1010428317716248.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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