DEK

This gene encodes a protein with one SAP domain. This protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA, and is also involved in splice site selection during mRNA processing. Chromosomal aberrations involving this region, increased expression of this gene, and the presence of antibodies against this protein are all associated with various diseases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

DEK Proto-Oncogene

Involved in chromatin organization.

Chromatin organization Source: UniProtKB-KW
Granulocyte differentiation Source: Reactome
Positive regulation of gene expression, epigenetic Source: Reactome
Regulation of double-strand break repair Source: MGI
Regulation of transcription by RNA polymerase II Source: Reactome
Signal transduction Source: ProtInc
Transcription by RNA polymerase II Source: ProtInc
Viral genome replication Source: ProtInc

Nucleus. Enriched in regions where chromatin is decondensed or sparse in the interphase nuclei.

A chromosomal aberration involving DEK is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia (PubMed:1549122). Translocation t(6;9)(p23;q34) with NUP214/CAN (PubMed:1549122). It results in the formation of a DEK-NUP214 fusion gene (PubMed:1549122).

Phosphorylated by CK2. Phosphorylation fluctuates during the cell cycle with a moderate peak during G1 phase, and weakens the binding of DEK to DNA.