DEK

This gene encodes a protein with one SAP domain. This protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA, and is also involved in splice site selection during mRNA processing. Chromosomal aberrations involving this region, increased expression of this gene, and the presence of antibodies against this protein are all associated with various diseases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
Full Name
DEK Proto-Oncogene
Function
Involved in chromatin organization.
Biological Process
Chromatin organization Source: UniProtKB-KW
Granulocyte differentiation Source: Reactome
Positive regulation of gene expression, epigenetic Source: Reactome
Regulation of double-strand break repair Source: MGI
Regulation of transcription by RNA polymerase II Source: Reactome
Signal transduction Source: ProtInc
Transcription by RNA polymerase II Source: ProtInc
Viral genome replication Source: ProtInc
Cellular Location
Nucleus. Enriched in regions where chromatin is decondensed or sparse in the interphase nuclei.
Involvement in disease
A chromosomal aberration involving DEK is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia (PubMed:1549122). Translocation t(6;9)(p23;q34) with NUP214/CAN (PubMed:1549122). It results in the formation of a DEK-NUP214 fusion gene (PubMed:1549122).
PTM
Phosphorylated by CK2. Phosphorylation fluctuates during the cell cycle with a moderate peak during G1 phase, and weakens the binding of DEK to DNA.
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Anti-DEK antibodies

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Mouse Anti-DEK Recombinant Antibody (CBYCD-241) (CBMAB-D0699-YC)

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Target: DEK
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat
Clone: CBYCD-241
Application*: WB, IH, IF
Datasheet SDS

Mouse Anti-DEK Recombinant Antibody (D0698) (CBMAB-D0698-YC)

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Target: DEK
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: D0698
Application*: IF, IH
Datasheet SDS

Mouse Anti-DEK Recombinant Antibody (20G19) (CBMAB-D0697-YC)

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Target: DEK
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 20G19
Application*: WB, IH
Datasheet SDS

Rabbit Anti-DEK Recombinant Antibody (
20D2) (V2LY-0725-LY1375)

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Target: DEK
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 20D2
Application*: E, IH, IF, F
Datasheet SDS

Rabbit Anti-DEK Recombinant Antibody (CP0455) (V2LY-0425-LY172)

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Target: DEK
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: CP0455
Application*: WB
Datasheet SDS

Mouse Anti-DEK Recombinant Antibody (D0696) (V2LY-0425-LY168)

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Target: DEK
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: D0696
Application*: WB, IF, IP
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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