Sign in or Register   Sign in or Register
  |  

Mouse Anti-DEPDC1 Recombinant Antibody (CBYCD-243) (CBMAB-D0705-YC)

Provided herein is a Mouse monoclonal antibody, which binds to DEP Domain Containing 1 (DEPDC1). The antibody can be used for immunoassay techniques, such as ELISA, IF, WB.
See all DEPDC1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYCD-243
Antibody Isotype
IgG2a, λ
Application
ELISA, IF, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, λ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 93-187

Target

Full Name
DEP domain containing 1
Introduction
DEPDC1 (DEP Domain Containing 1) is a protein coding gene. Diseases associated with DEPDC1 include Bladder Cancer. It has proved that the protein has GTPase activator activity. And a paralog is DEPDC1B.
Entrez Gene ID
55635
UniProt ID
Q5TB30
Alternative Names
DEP Domain Containing 1; DEPDC1A; DEP Domain-Containing Protein 1A; Cell Cycle Control Protein SDP35; DEPDC1-V2; DEP.8; SDP35;
Function
May be involved in transcriptional regulation as a transcriptional corepressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells.
Biological Process
Intracellular signal transduction Source: InterPro
Negative regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of GTPase activity Source: GOC
Cellular Location
Nucleus. Colocalizes with ZNF224 at the nucleus.

Wang, Q., Jiang, S., Liu, J., Ma, G., Zheng, J., & Zhang, Y. (2021). DEP Domain Containing 1 Promotes Proliferation, Invasion, and Epithelial–Mesenchymal Transition in Colorectal Cancer by Enhancing Expression of Suppressor of Zest 12. Cancer Biotherapy & Radiopharmaceuticals, 36(1), 36-44.

Li, Y. Y., Li, W., Chang, G. Z., & Li, Y. M. (2021). Long noncoding RNA KTN1 antisense RNA 1exerts an oncogenic function in lung adenocarcinoma by regulating DEP domain containing 1 expression via activating epithelial–mesenchymal transition. Anti-Cancer Drugs, 32(6), 614-625.

Shen, X., & Han, J. (2020). Overexpression of gene DEP domain containing 1 and its clinical prognostic significance in colorectal cancer. Journal of Clinical Laboratory Analysis, 34(12), e23634.

Guo, W., Li, H., Liu, H., Ma, X., Yang, S., & Wang, Z. (2019). DEPDC1 drives hepatocellular carcinoma cell proliferation, invasion and angiogenesis by regulating the CCL20/CCR6 signaling pathway. Oncology reports, 42(3), 1075-1089.

Qu, D., Cui, F., Lu, D., Yang, Y., & Xu, Y. (2019). DEP domain containing 1 predicts prognosis of hepatocellular carcinoma patients and regulates tumor proliferation and metastasis. Cancer Science, 110(1), 157-165.

Hao, S., Tian, W., Chen, Y., Wang, L., Jiang, Y., Gao, B., & Luo, D. (2019). MicroRNA‐374c‐5p inhibits the development of breast cancer through TATA‐box binding protein associated factor 7‐mediated transcriptional regulation of DEP domain containing 1. Journal of cellular biochemistry, 120(9), 15360-15368.

Zhao, H., Yu, M., Sui, L., Gong, B., Zhou, B., Chen, J., ... & Hao, C. (2019). High expression of DEPDC1 promotes malignant phenotypes of breast cancer cells and predicts poor prognosis in patients with breast cancer. Frontiers in oncology, 9, 262.

Li, A., Wang, Q., He, G., Jin, J., & Huang, G. (2018). DEP domain containing 1 suppresses apoptosis via inhibition of A20 expression, which activates the nuclear factor κB signaling pathway in HepG2 cells. Oncology letters, 16(1), 949-955.

Wang, Q., Li, A., Jin, J., & Huang, G. (2017). Targeted interfering DEP domain containing 1 protein induces apoptosis in A549 lung adenocarcinoma cells through the NF-κB signaling pathway. OncoTargets and therapy, 10, 4443.

Huang, L., Chen, K., Cai, Z. P., Chen, F. C., Shen, H. Y., Zhao, W. H., ... & Lin, X. (2017). DEPDC1 promotes cell proliferation and tumor growth via activation of E2F signaling in prostate cancer. Biochemical and biophysical research communications, 490(3), 707-712.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-DEPDC1 Recombinant Antibody (CBYCD-243)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare