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DEPDC1

DEPDC1 (DEP Domain Containing 1) is a Protein Coding gene. Diseases associated with DEPDC1 include Bladder Cancer. Gene Ontology (GO) annotations related to this gene include GTPase activator activity. An important paralog of this gene is DEPDC1B.

Full Name

DEP domain containing 1

Function

May be involved in transcriptional regulation as a transcriptional corepressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells.

Biological Process

Intracellular signal transduction Source: InterPro
Negative regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of GTPase activity Source: GOC

Cellular Location

Nucleus. Colocalizes with ZNF224 at the nucleus.

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Anti-DEPDC1 antibodies

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Mouse Anti-DEPDC1 Recombinant Antibody (6H1) (CBMAB-A2187-LY)

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Target: DEPDC1

Host: Mouse

Antibody Isotype: IgG2a, λ

Specificity: Human

Clone: 6H1

Application*: WB, E

Mouse Anti-DEPDC1 Recombinant Antibody (6H1) (V2LY-0425-LY195)

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Target: DEPDC1

Host: Mouse

Antibody Isotype: IgG2a, λ

Specificity: Human

Clone: 6H1

Application*: WB, IP, IF, E

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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