DEPDC1

DEPDC1 (DEP Domain Containing 1) is a Protein Coding gene. Diseases associated with DEPDC1 include Bladder Cancer. Gene Ontology (GO) annotations related to this gene include GTPase activator activity. An important paralog of this gene is DEPDC1B.

Full Name

DEP domain containing 1

Function

May be involved in transcriptional regulation as a transcriptional corepressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells.

Biological Process

Intracellular signal transduction Source: InterPro
Negative regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of GTPase activity Source: GOC

Cellular Location

Nucleus. Colocalizes with ZNF224 at the nucleus.

Anti-DEPDC1 antibodies

Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Mouse Anti-DEPDC1 Recombinant Antibody (6H1) (CBMAB-A2187-LY)

Datasheet

SDS

Target: DEPDC1

Host: Mouse

Antibody Isotype: IgG2a, λ

Specificity: Human

Clone: 6H1

Application*: WB, E

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)