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Mouse Anti-DNER Monoclonal Antibody (DR324-4) (CBMAB-1036-YC)

Provided herein is a mouse monoclonal antibody against Human DNER. The antibody, clone DR324-4, can be used for immunoassay techniques, such as ELISA and WB.
See all DNER antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
DR324-4
Antibody Isotype
IgG2a
Application
ELISA, WB

Basic Information

Immunogen
Recombinant human DNER (extracellular domain)
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
Located in extracellular Domain

Target

Full Name
delta/notch-like EGF repeat containing
Introduction
DNER is an activator of the NOTCH1 pathway which may mediate neuron-glia interaction during astrocytogenesis.
Entrez Gene ID
UniProt ID
Alternative Names
bet; UNQ26
Function
Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis (By similarity).
Biological Process
Central nervous system development Source: UniProtKB
Endocytosis Source: UniProtKB
Glial cell differentiation Source: Ensembl
Neuron migration Source: UniProtKB
Notch receptor processing Source: Ensembl
Notch signaling pathway Source: UniProtKB-KW
Skeletal muscle fiber development Source: Ensembl
Synapse assembly Source: UniProtKB
Cellular Location
Cell membrane. Present on the membrane of dendrites and cell bodies but excluded from axonal membrane. Also found in early endosomes in the somatodendritic region (By similarity).
Topology
Extracellular: 35-640
Helical: 641-661
Cytoplasmic: 662-737

Campana, I. G., & Silva, G. D. (2021). Anti-Tr/DNER Antibody–Associated Cerebellar Ataxia: a Systematic Review. The Cerebellum, 1-7.

Wang, Z., Li, Z., Wu, Q., Li, C., Li, J., Zhang, Y., ... & Sun, S. (2020). DNER promotes epithelial–mesenchymal transition and prevents chemosensitivity through the Wnt/β-catenin pathway in breast cancer. Cell death & disease, 11(8), 1-16.

Ballester-López, C., Conlon, T. M., Ertüz, Z., Greiffo, F. R., Irmler, M., Verleden, S. E., ... & Yildirim, A. Ö. (2019). The Notch ligand DNER regulates macrophage IFNγ release in chronic obstructive pulmonary disease. EBioMedicine, 43, 562-575.

Wang, L., Wu, Q., Li, Z., Sun, S., Yuan, J., Li, J., ... & Sun, S. (2019). Delta/notch-like epidermal growth factor-related receptor promotes stemness to facilitate breast cancer progression. Cellular signalling, 63, 109389.

Wang, L., Wu, Q., Zhu, S., Li, Z., Yuan, J., Liu, L., ... & Wang, C. (2018). Quantum dot-based immunofluorescent imaging and quantitative detection of DNER and prognostic value in prostate cancer. Cancer Biomarkers, 22(4), 683-691.

Du, J., Wang, X., Zhang, X., Zhang, X., & Jiang, H. (2018). DNER modulates the length, polarity and synaptogenesis of spiral ganglion neurons via the Notch signaling pathway. Molecular Medicine Reports, 17(2), 2357-2365.

Keeley, P. W., & Reese, B. E. (2018). DNER and NFIA are expressed by developing and mature AII amacrine cells in the mouse retina. Journal of Comparative Neurology, 526(3), 467-479.

Wang, L., Wu, Q., Zhu, S., Li, Z., Yuan, J., Yu, D., ... & Wang, C. (2017). Delta/notch-like epidermal growth factor-related receptor (DNER) orchestrates stemness and cancer progression in prostate cancer. American journal of translational research, 9(11), 5031.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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