Mouse Anti-DNER Recombinant Antibody (4E8) (CBMAB-1037-YC)

Name: Mouse Anti-DNER Recombinant Antibody (4E8)
SKU: CBMAB-1037-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

4E8

Application

ELISA, WB

Immunogen

DNER (aa368-476) partial recombinant protein.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG3, κ

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

Batch dependent

Purity

>95%, as determined by SDS-PAGE analysis

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

Located in aa 368-477

More Infomation

Target

Full Name

delta/notch-like EGF repeat containing

Introduction

DNER is an activator of the NOTCH1 pathway which may mediate neuron-glia interaction during astrocytogenesis.

Entrez Gene ID

92737

UniProt ID

Q8NFT8

Alternative Names

bet; UNQ26

Function

Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis (By similarity).

Biological Process

Central nervous system development Source: UniProtKB
Endocytosis Source: UniProtKB
Glial cell differentiation Source: Ensembl
Neuron migration Source: UniProtKB
Notch receptor processing Source: Ensembl
Notch signaling pathway Source: UniProtKB-KW
Skeletal muscle fiber development Source: Ensembl
Synapse assembly Source: UniProtKB

Cellular Location

Cell membrane. Present on the membrane of dendrites and cell bodies but excluded from axonal membrane. Also found in early endosomes in the somatodendritic region (By similarity).

Topology

Extracellular: 35-640
Helical: 641-661
Cytoplasmic: 662-737

Campana, I. G., & Silva, G. D. (2021). Anti-Tr/DNER Antibody–Associated Cerebellar Ataxia: a Systematic Review. The Cerebellum, 1-7.

Wang, Z., Li, Z., Wu, Q., Li, C., Li, J., Zhang, Y., ... & Sun, S. (2020). DNER promotes epithelial–mesenchymal transition and prevents chemosensitivity through the Wnt/β-catenin pathway in breast cancer. Cell death & disease, 11(8), 1-16.

Ballester-López, C., Conlon, T. M., Ertüz, Z., Greiffo, F. R., Irmler, M., Verleden, S. E., ... & Yildirim, A. Ö. (2019). The Notch ligand DNER regulates macrophage IFNγ release in chronic obstructive pulmonary disease. EBioMedicine, 43, 562-575.

Wang, L., Wu, Q., Li, Z., Sun, S., Yuan, J., Li, J., ... & Sun, S. (2019). Delta/notch-like epidermal growth factor-related receptor promotes stemness to facilitate breast cancer progression. Cellular signalling, 63, 109389.

Wang, L., Wu, Q., Zhu, S., Li, Z., Yuan, J., Liu, L., ... & Wang, C. (2018). Quantum dot-based immunofluorescent imaging and quantitative detection of DNER and prognostic value in prostate cancer. Cancer Biomarkers, 22(4), 683-691.

Du, J., Wang, X., Zhang, X., Zhang, X., & Jiang, H. (2018). DNER modulates the length, polarity and synaptogenesis of spiral ganglion neurons via the Notch signaling pathway. Molecular Medicine Reports, 17(2), 2357-2365.

Keeley, P. W., & Reese, B. E. (2018). DNER and NFIA are expressed by developing and mature AII amacrine cells in the mouse retina. Journal of Comparative Neurology, 526(3), 467-479.

Wang, L., Wu, Q., Zhu, S., Li, Z., Yuan, J., Yu, D., ... & Wang, C. (2017). Delta/notch-like epidermal growth factor-related receptor (DNER) orchestrates stemness and cancer progression in prostate cancer. American journal of translational research, 9(11), 5031.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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