Human DNER ELISA Kit (V2LY-0626-LY4484)

Name: Human DNER ELISA Kit
SKU: V2LY-0626-LY4484
Rating: 5 (1 reviews)

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Tested Data

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity

0.016 ng/mL

Detection Range

0.05-20 ng/mL

Sample Type

Serum, Plasma, cell culture supernates

Specificity

Human

Assay Type

Sandwich

Reactivity

Human

Assay Time

1.5 h

Molecule Mass

78.5 kDa

Components

Pre-coated ELISA Plate: 12 wells * 8 detachable strips
Standard solution: 0.5ml x1
Standard diluent: 3ml x1
Streptavidin-HRP: 6ml x1
Stop solution: 6ml x1
Substrate solution A: 6ml x1
Substrate solution B: 6ml x1
Wash buffer concentrate (25x): 20ml x1
Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 2-8°C

More Infomation

Target

Full Name

delta/notch-like EGF repeat containing

Function

Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis (By similarity).

Biological Process

Central nervous system development Source: UniProtKB
Endocytosis Source: UniProtKB
Glial cell differentiation Source: Ensembl
Neuron migration Source: UniProtKB
Notch receptor processing Source: Ensembl
Notch signaling pathway Source: UniProtKB-KW
Skeletal muscle fiber development Source: Ensembl
Synapse assembly Source: UniProtKB

Cellular Location

Cell membrane. Present on the membrane of dendrites and cell bodies but excluded from axonal membrane. Also found in early endosomes in the somatodendritic region (By similarity).

Topology

Extracellular: 35-640
Helical: 641-661
Cytoplasmic: 662-737

Campana, I. G., & Silva, G. D. (2021). Anti-Tr/DNER Antibody–Associated Cerebellar Ataxia: a Systematic Review. The Cerebellum, 1-7.

Wang, Z., Li, Z., Wu, Q., Li, C., Li, J., Zhang, Y., ... & Sun, S. (2020). DNER promotes epithelial–mesenchymal transition and prevents chemosensitivity through the Wnt/β-catenin pathway in breast cancer. Cell death & disease, 11(8), 1-16.

Ballester-López, C., Conlon, T. M., Ertüz, Z., Greiffo, F. R., Irmler, M., Verleden, S. E., ... & Yildirim, A. Ö. (2019). The Notch ligand DNER regulates macrophage IFNγ release in chronic obstructive pulmonary disease. EBioMedicine, 43, 562-575.

Wang, L., Wu, Q., Li, Z., Sun, S., Yuan, J., Li, J., ... & Sun, S. (2019). Delta/notch-like epidermal growth factor-related receptor promotes stemness to facilitate breast cancer progression. Cellular signalling, 63, 109389.

Wang, L., Wu, Q., Zhu, S., Li, Z., Yuan, J., Liu, L., ... & Wang, C. (2018). Quantum dot-based immunofluorescent imaging and quantitative detection of DNER and prognostic value in prostate cancer. Cancer Biomarkers, 22(4), 683-691.

Du, J., Wang, X., Zhang, X., Zhang, X., & Jiang, H. (2018). DNER modulates the length, polarity and synaptogenesis of spiral ganglion neurons via the Notch signaling pathway. Molecular Medicine Reports, 17(2), 2357-2365.

Keeley, P. W., & Reese, B. E. (2018). DNER and NFIA are expressed by developing and mature AII amacrine cells in the mouse retina. Journal of Comparative Neurology, 526(3), 467-479.

Wang, L., Wu, Q., Zhu, S., Li, Z., Yuan, J., Yu, D., ... & Wang, C. (2017). Delta/notch-like epidermal growth factor-related receptor (DNER) orchestrates stemness and cancer progression in prostate cancer. American journal of translational research, 9(11), 5031.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Rat Anti-DNER Recombinant Antibody (D1355) (CAT#: V2LY-0425-LY681)

Mouse Anti-DNER Recombinant Antibody (2F3) (CAT#: CBMAB-D1354-YC)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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